恶性肿瘤骨转移应用唑来膦酸后并发下颌骨坏死的治疗研究进展  

Research Progress in the Treatment of Mandibular Necrosis after Zoledronic Acid in Malignant Tumor Bone Metastasis

作　　者：张薇 于忠和 张秀良 刁永恩 代忠 ZHANG Wei;YU Zhong-He;ZHANG Xiu-Liang;DIAO Yong-En;DAI Zhong(Department of Oncology,Beijing Chaoyang integrated traditional Chinese and Western medicine emergency rescue center,Beijing 100122,China;Department of General Internal Medicine,Beijing Guangxi rehabilitation hospital,Beijing 100020,China;Department of General Internal Medicine,Huanxing Tumor Hospital,Chaoyang District,Beijing 100122,China)

机构地区：[1]北京朝阳中西医结合急诊抢救中心肿瘤科,北京100122 [2]北京光熙康复医院综合内科,北京100020 [3]北京市朝阳区桓星肿瘤医院综合内科,北京100122

出　　处：《中国药物经济学》2023年第6期117-119,123,共4页China Journal of Pharmaceutical Economics

基　　金：北京朝阳区科技计划(CYSF2045)。

摘　　要：下颌骨坏死是唑来膦酸潜在的一种严重并发症,患者会出现骨暴露、缺血性骨坏死等典型临床症状表现,同时可能伴有颌面部瘘管、疼痛、病理性骨折等,对患者的治疗效果和日常生活等均产生严重影响。药物的药理作用、感染因素、创伤因素、致病基因等均是导致下颌骨坏死的发病因素,对于该病的治疗,临床上采用了全身抗生素治疗、手术治疗、激光治疗、局部冲洗含漱、高压氧舱等措施,但效果均不理想。本文将对恶性肿瘤骨转移应用唑来膦酸后并发下颌骨坏死的临床特点、发病机制和临床治疗进展进行综述。Mandibular necrosis is a potential serious complication of zoledronic acid.Patients will have typical clinical symptoms such as bone exposure and ischemic bone necrosis,and may be accompanied by maxillofacial fistula,pain,pathological fracture,etc.,which will have a serious impact on the treatment effect and daily life of patients.The pharmacological effects of drugs,infection factors,trauma factors,pathogenic genes,etc.are all the pathogenic factors leading to mandibular necrosis.For the treatment of this disease,systemic antibiotic treatment,surgical treatment,laser treatment,local rinsing and rinsing,hyperbaric oxygen chamber and other measures have been used clinically,but the effect is not very ideal.This article will review the clinical characteristics,pathogenesis and clinical treatment progress of mandibular necrosis after zoledronic acid is applied to malignant tumor bone metastasis.

关 键 词：恶性肿瘤骨转移 唑来膦酸 下颌骨坏死 

分 类 号：R73-37[医药卫生—肿瘤] R979.1[医药卫生—临床医学]