Oncotype DX方法和Magee方程对乳腺癌预后预测价值的研究进展  

Research development on the prognostic value of oncotype DX and Magee equation in breast cancer

作　　者：卢洪胜 陈琪 陈毓 潘印 赵澄泉[4] LU Hongsheng;CHEN Qi;CHEN Yu;PAN Yin;ZHAO Chengquan(Department of Pathology,Taizhou Central Hospital(Taizhou University Hospital),Taizhou 318000,China;Precision Medicine Center,Taizhou Central Hospital(Taizhou University Hospital),Taizhou 318000,China;Department of Surgical Oncology,Taizhou Central Hospital(Taizhou University Hospital),Taizhou 318000,China;Department of Pathology,Magee-Women’s Hospital of Medical Center of Pittsburgh University,Pennsylvania 15213,USA)

机构地区：[1]台州市中心医院(台州学院附属医院)病理科,浙江台州318000 [2]台州市中心医院(台州学院附属医院)精准医学中心,浙江台州318000 [3]台州市中心医院(台州学院附属医院)肿瘤外科,浙江台州318000 [4]美国匹兹堡大学医学中心Magee妇女医院病理科,宾夕法尼亚州匹兹堡15213

出　　处：《温州医科大学学报》2023年第8期684-688,F0003,共6页Journal of Wenzhou Medical University

基　　金：台州市科技计划项目(22ywa20)。

摘　　要：全球癌症统计数据显示,乳腺癌已成为全球女性发病率最高的恶性肿瘤。随着分子生物学的迅速发展,乳腺癌标准药物治疗策略是西方国家推进乳腺癌个体化精准治疗的主要组成部分。Oncotype DX是一种成熟的、食品药品监督管理局(FDA)批准的多基因检测工具,主要用于预测恶性肿瘤复发及转移风险,可指导雌激素受体(ER)阳性/人表皮生长因子受体2(HER2)阴性早期浸润性乳腺癌患者的化疗。基于现有的病理参数和乳腺癌症生物标志物,Magee方程是一种新颖、经济高效的算法,有可能替代Oncotype DX复发评分,并且已越来越常用于乳腺癌的临床管理。笔者就Oncotype DX方法与Magee方程对乳腺癌患者预后的预测价值进行总结评论,为临床治疗提供参考。Objective:The latest global cancer statistics showed that breast cancer has become the top malignancy in female worldwide.With the rapid development of molecular biology,the standard medication strategy for breast cancer is the major component of promoting individualized precision therapy in Western countries.Oncotype DX is a well-established multigene genomic assay,approved by the Food and Drug Administration(FDA)to predict the risk of cancer recurrence and metastasis,and guide proper chemotherapy in patients with estrogen receptor(ER)-positive/human epidermal growth factor receptor 2(HER2)-negative early invasive breast cancers.Subsequently,based on currently available pathologic parameters and breast cancer biomarkers,Magee equation as a novel and cost-effective algorithm,which is proposed to simulate Oncotype DX recurrence score,has been commonly applied in clinical administration of breast cancer.This review summarizes the predictive value of Oncotype DX method and Magee equation for the breast cancer prognosis in patients,which might provide a suitable reference for clinical management.

关 键 词：乳腺癌 Oncotype DX Magee方程 复发评分 

分 类 号：R737.9[医药卫生—肿瘤]