Degradable nanocatalyst enables antitumor/antibacterial therapy and promotion of wound healing for diabetes via self-enhanced cascading reaction  

作　　者：Xiang Wang Cheng Ding Ziwen Zhang Chunlin Li Dongmiao Cao Linjing Zhao Guoying Deng Yu Luo Chunping Yuan Jie Lu Xijian Liu 

机构地区：[1]School of Chemistry and Chemical Engineering,Shanghai Engineering Technology Research Center for Pharmaceutical Intelligent Equipment,Shanghai Frontiers Science Research Center for Druggability of Cardiovascular Noncoding RNA,Institute for Frontier Medical Technology,Shanghai University of Engineering Science,Shanghai201620,China [2]Affiliated Sixth People's Hospital,Shanghai JiaoTong University,Shanghai 200233,China [3]Trauma Center,Shanghai General Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 201620,China

出　　处：《Chinese Chemical Letters》2023年第7期155-161,共7页中国化学快报（英文版）

基　　金：supported by the Laboratory Animal Welfare and Ethics Committee of the Clinical Center of Shanghai First People's Hospital (No. 2020AWS0065);financially supported by the National Natural Science Foundation of China (Nos. 21978165, 92156020);Science and Technology Commission of Shanghai (No. 20DZ2255900);Class Ⅲ Peak Discipline of Shanghai—Materials Science and Engineering (High-Energy Beam Intelligent Processing and Green Manufacturing)。

摘　　要：Diabetic patients often have problems such as residual tumor and wound infection after tumor resection,causing severe clinical problems.It is urgent to develop effective therapies to reach oncotherapy/antiinfection/promotion of wound healing combined treatment.Herein,we propose CS/MnO_(2)-GO_x (CMGO_x)nanocatalysts for the specific catalytic generation of ~·OH to inhibit tumors and bacteria in a hyperglycemic environment.The good biocompatible chitosan (CS),as a carrier for the catalyst,exhibits excellent antibacterial effect as well as promotes wound healing.Glucose oxidase (GO_x) is loaded on the surface of CS nanoparticles to generate H_(2)O_(2) and gluconic acid by consuming glucose (starvation therapy,ST) and O_(2).The MnO_(2) depletes glutathione (GSH) to produce Mn^(2+),amplifying oxidative stress and further promoting the activity of Mn^(2+)-mediated Fenton-like reaction to produce~·OH (chemodynamic therapy,CDT)in weak acidic environment.Moreover,the produced gluconic acid lowers the p H of the environment,enhancing chemodynamic therapy (ECDT).The tumor cells and bacteria are efficiently eliminated by the synergistic effect of ST and ECDT.The MnO_(2) nanoparticles at neutral environment decomposes H_(2)O_(2) into O_(2),which cooperate with CS to promote healing.The self-enhanced cascade reaction of CMGO_x in situ exhibits excellent effects of antitumor/antibacterial therapy and promotion of wound healing,offering a promising integrated treatment for diabetic patients after tumor surgical resection.

关 键 词：Self-cascade reaction Starvation therapy Chemodynamic therapy ANTITUMOR ANTIBACTERIAL Wound healing 

分 类 号：R587.1[医药卫生—内分泌] TQ426[医药卫生—内科学] TB383.1[医药卫生—临床医学]