中国10个地区成年人外周血嵌合染色体变异的流行病学分布特征  

Epidemiological distribution characteristics of peripheral blood mosaic chromosomal alteration in adults from 10 regions of China

作　　者：宋明钰 赵禹碹 韩雨廷 吕筠[1,2] 余灿清[1,2] 裴培 杜怀东[3,4] 陈君石 陈铮鸣[4] 孙点剑一 李立明[1,2] 中国慢性病前瞻性研究项目协作组 Song Mingyu;Zhao Yuxuan;Han Yuting;Lyu Jun;Yu Canqing;Pei Pei;Du Huaidong;Chen Junshi;Chen Zhengming;Sun Dianjianyi;Li Liming;China Kadoorie Biobank Collaborative Group(Key Laboratory of Epidemiology of Major Diseases,Ministry of Education/Department of Epidemiology and Biostatistics,School of Public Health,Peking University,Beijing 100191,China;Peking University Center for Public Health and Epidemic Preparedness&Response,Beijing 100191,China;Medical Research Council Population Health Research Unit,University of Oxford,Oxford OX37LF,United Kingdom;Clinical Trial Service Unit and Epidemiological Studies Unit,Nuffield Department of Population Health,University of Oxford,Oxford OX37LF,United Kingdom;China National Center for Food Safety Risk Assessment,Beijing 100022,China;不详)

机构地区：[1]北京大学公共卫生学院流行病与卫生统计学系/重大疾病流行病学教育部重点实验室,北京100191 [2]北京大学公众健康与重大疫情防控战略研究中心,北京100191 [3]英国牛津大学医学研究委员会人口健康研究组,牛津OX37LF [4]英国牛津大学临床与流行病学研究中心纳菲尔德人群健康系,牛津OX37LF [5]国家食品安全风险评估中心,北京100022 [6]不详

出　　处：《中华流行病学杂志》2023年第7期1021-1026,共6页Chinese Journal of Epidemiology

基　　金：国家自然科学基金(82103920,82192901,82192904,82192900);英国Wellcome Trust(212946/Z/18/Z,202922/Z/16/Z,104085/Z/14/Z,088158/Z/09/Z);中国香港Kadoorie Charitable基金。

摘　　要：目的描述外周血嵌合染色体变异(mCA)在我国10个地区30~79岁自然人群的流行病学分布特征。方法纳入中国慢性病前瞻性研究(CKB)10个项目地区中已有基线数据(人口学特征、生活方式、体格检查等)和外周血基因分型数据的100297名研究对象,通过嵌合染色体变异工作流计算mCA表型检出率,采用logistic回归比较mCA检出率在不同地区、不同特征人群间的分布差异。结果共检出5810名mCA携带者,检出率为5.8%,标化后检出率为5.1%。mCA检出率随基线年龄增长逐渐升高,30~、51~、>60岁人群检出率分别为3.4%、5.0%和9.4%(趋势检验P<0.001);男性检出率(8.0%)高于女性(4.0%),城市检出率(6.4%)高于农村(5.3%),差异均有统计学意义(P<0.001)。调整年龄、性别和10个地区后,当前吸烟或因病戒烟者、低体力活动水平者mCA检出率较高,肥胖者mCA检出率(5.3%)低于正常体重者(5.9%),差异有统计学意义(P=0.006)。结论我国10个地区30~79岁自然人群的mCA检出率存在地区和人群分布差异。相关结果有助于识别分子衰老人群,指导肿瘤等年龄相关疾病的精准预防。Objective To describe the epidemiological distribution characteristics of peripheral blood mosaic chromosomal alteration(mCA)in community adults aged 30-79 years in 10 regions of China.Methods A total of 100297 participants with complete baseline information(demographic characteristics,lifestyle,physical examination,etc.)and genotyping data of blood-derived DNA in ten regions of the China Kadoorie Biobank study were included.The mCAs were detected with the Mosaic Chromosomal Alterations pipeline,and logistic regression models were used to compare the differences in the detection rate of mCAs in different regions and populations.Results A total of 5810 mCA carriers were detected,with the detection rate of 5.8%.The standardized detection rate was 5.1%.The baseline detection rate of mCA increased with age,which were 3.4%,5.0%,and 9.4%in those aged 30-,51-,and>60 years,respectively(trend test P<0.001).A more significant proportion of mCAs were found in men(8.0%)than women(4.0%),as well as in urban areas(6.4%)than in rural areas(5.3%),the difference was significant(P<0.001).After adjusting for age and gender,the detection rate of mCA was higher in current smokers or people quitting smoking due to illness and people with low physical activity level,and the mCA detection rate was lower in obesy people(5.3%)than that in people with normal body weight(5.9%)(P=0.006).Conclusions The detection rate of mCAs varied with region and population in community adults aged 30-79 years in 10 regions of China.The study results might contribute to the molecular identification of aging populations and guide precision prevention of age-related diseases such as cancers.

关 键 词：嵌合染色体变异 流行分布 体细胞突变 

分 类 号：R181.3[医药卫生—流行病学] R596.1[医药卫生—公共卫生与预防医学]