吡咯啉-5-羧酸还原酶-1在肿瘤中的作用及机制研究进展  

Research progress on the role and mechanism of pyrrolin-5-carboxylate reductase-1 in tumor

作　　者：周波蓉 宋雅楠(综述)[1] 夏伟(审校)[1] ZHOU Borong;SONG Yanan;XIA Wei(Department of Nuclear Medicine,The Seventh People′s Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200137,China)

机构地区：[1]上海中医药大学附属第七人民医院核医学科,上海200137

出　　处：《实用肿瘤学杂志》2023年第3期267-271,共5页Practical Oncology Journal

基　　金：上海市浦东新区卫生系统领先人才培养计划(编号:PWRI2019-03);上海市浦东新区科技发展基金民生科研专项(编号:PKJ2021-Y04);上海市科学技术委员会生物医药科技支撑专项(编号:20S21901900)。

摘　　要：吡咯啉-5-羧酸还原酶-1(Pyrroline-5-Carboxylate Reductase-1,PYCR1)是线粒体脯氨酸合成的关键酶。越来越多的研究表明PYCR1在多种恶性肿瘤中高表达,影响肿瘤细胞增殖、凋亡、侵袭和迁移等生物学行为,且与临床预后密切相关,有望成为新的肿瘤生物标志物,但其涉及的作用机制比较复杂。本文将从PYCR1在肿瘤中的作用机制、临床意义以及PYCR1抑制剂对肿瘤的影响三个方面综述PYCR1在肿瘤发生发展中的作用。Pyrroline-5-Carboxylate Reductase-1(PYCR1)is a key enzyme for synthesis of mitochondrial proline.More and more studies have shown that PYCR1 is highly expressed in various malignant tumors,affecting the biological behaviors such as tumor cell proliferation,apoptosis,invasion and migration,and is closely related to clinical prognosis.It is expected to become a new tumor biomarker,but its mechanism of action is relatively complex.This article will review the role of PYCR1 in tumorigenesis and development from three aspects:its mechanism of action,clinical significance and the effect of PYCR1 inhibitors on tumors.

关 键 词：PYCR1 脯氨酸 肿瘤 作用机制 

分 类 号：R730.1[医药卫生—肿瘤]