血清炎性细胞因子和人血管生成素受体酪氨酸激酶2水平与首发精神分裂症患者临床症状的相关性  

Serum inflammatory cytokines and Tie-2 correlation with clinical symptoms in patients with first-episode schizophrenia

作　　者：王安珍 张许来[1,2,3,4] 严凡凡 孟小靖[1,2,3,4] 程夏龙 Wang Anzhen;Zhang Xulai;Yan Fanfan;Meng Xiaojing;Cheng Xialong(Affiliated Psychological Hospital of Anhui Medical University,Hefei 230022;Anhui Mental Health Center,Hefei 230022;Hefei Fourth People's Hospital,Hefei 230022;Anhui Clinical Research Center for Mental Disorders,Hefei 230022)

机构地区：[1]安徽医科大学附属心理医院,合肥230022 [2]安徽省精神卫生中心,合肥230022 [3]合肥市第四人民医院,合肥230022 [4]安徽省精神心理疾病临床研究中心,合肥230022

出　　处：《安徽医科大学学报》2023年第8期1393-1397,共5页Acta Universitatis Medicinalis Anhui

基　　金：安徽省重点研究和开发计划项目(编号:201904a07020009)。

摘　　要：目的探究首发精神分裂症患者与健康人群的血清炎性细胞因子和人血管生成素受体酪氨酸激酶2(Tie-2)水平差异,及其与临床症状的相关性。方法本研究共招募了168例参与者,包括86例首发精神分裂症患者(患者组)和82例健康人群(对照组)。在基线时收集人口统计学数据、阳性和阴性症状量表(PANSS)和简明精神病评定量表(BPRS)的评估结果和血液样本,采用超敏感电化学发光检测技术(MSD)测定血清炎性细胞因子和Tie-2水平。结果与对照组比较,患者组的血清白细胞介素(IL)-1β、IL-4水平升高(P<0.05),Tie-2水平降低(P<0.05)。患者组IL-1β水平与BPRS总分、BPRS敌对猜疑因子分、PANSS阳性量表因子分呈正相关(P<0.05)。患者组PANSS阳性分和BPRS总分对IL-1β水平均有正性影响(P<0.05),患者组PANSS阴性量表因子分、一般精神病理量表因子分、PANSS总分对Tie-2水平也均有正性影响(P<0.05)。患者组IL-1β水平可以在1.181 pg/L的临界水平上有效预测首发精神分裂症患者临床症状的严重程度,特异性为0.850,敏感性为0.972。患者组Tie-2水平可以在2127.076 pg/L的临界水平上有效预测首发精神分裂症患者临床症状的严重程度,特异性为0.675,敏感性为0.639。IL-1β和Tie-2的AUC分别为0.8361和0.6462。结论首发精神分裂症患者的IL-1β、IL-4和Tie-2水平与健康人群存在差异性。首发精神分裂症患者的IL-1β水平与部分临床症状存在相关性。IL-1β和Tie-2水平可能是预测首发精神分裂症患者的发病症状严重程度较高敏感性和特异性的影响因子。Objective To explore the differences of serum inflammatory cytokines and tyrosine kinase with immunoglobulin and epidermal growth factor homology domains-2(Tie-2)levels between patients with first-episode schizophrenia and healthy people,and the correlation with clinical symptoms.Methods A total of 168 participants were recruited,including 86 patients with first-episode schizophrenia(patient group)and 82 healthy people(control group).Demographic data,Positive and Negative Symptom Scale(PANSS)and Brief Psychiatric Rating Scale(PANSS)were collected at baseline.Serum inflammatory cytokines and Tie-2 levels were determined by Meso Scale Discovery(MSD).Results Compared with the control group,the levels of serum interleukin(IL)-1β and IL-4 in the patient group increased(P<0.05),while the level of Tie-2 decreased(P<0.05).IL-1β level in the patient group was positively correlated with the total score of BPRS,the score of BPRS hostility factor and the score of PANSS positive scale factor(P<0.05).The positive score of PANSS and the total score of BPRS in the patient group had a positive effect on IL-1β level(P<0.05).PANSS negative scale factor score,general psychopathological scale factor score and total score of PANSS in patient group also had positive effects on Tie-2 level(P<0.05).IL-1β level in the patient group could effectively predict the severity of clinical symptoms in patients with first-episode schizophrenia at the critical level of 1.181 pg/L,with a specificity of 0.850 and a sensitivity of 0.972.Tie-2 level in the patient group can effectively predict the severity of clinical symptoms in patients with first-episode schizophrenia at the critical level of 2127.076 pg/L,with specificity of 0.675 and sensitivity of 0.639.The AUC of IL-1β and Tie-2 were 0.8361 and 0.6462,respectively.Conclusion The levels of IL-1β,IL-4 and Tie-2 in patients with first-episode schizophrenia are different from those in healthy people.IL-1β levels in patients with first-episode schizophrenia are correlated with part of clinical

关 键 词：首发精神分裂症 炎性因子 人血管生成素受体酪氨酸激酶2 影响因子 

分 类 号：R749.3[医药卫生—神经病学与精神病学]