2.5%NaClO溶液冲洗对大鼠炎症牙髓愈合影响  

The effect of 2.5%NaClO solution irrigation on dental pulp healing in rats with inflammatory pulp

作　　者：杨琪 唐颖 李午丽[2] 陈乔尔[3] 孙麟[3] 李颂[2] Yang Qi;Tang Ying;Li Wuli;Chen Qiaoer;Sun Lin;Li Song(School of Stomatology,Anhui Medical University,Hefei 230032;Dept of Dentistry,The Affiliated Stomatological Hospital of Anhui Medical University,Hefei 230032;Dept of Pathology,The Affiliated Stomatological Hospital of Anhui Medical University,Hefei 230032)

机构地区：[1]安徽医科大学口腔医学院,合肥230032 [2]安徽医科大学附属口腔医院牙体牙髓科,合肥230032 [3]安徽医科大学附属口腔医院病理科,合肥230032

出　　处：《安徽医科大学学报》2023年第8期1413-1417,共5页Acta Universitatis Medicinalis Anhui

基　　金：安徽高校自然科学研究项目(编号:KJ2020A0164)。

摘　　要：目的评估使用2.5%NaClO溶液作为冲洗剂对大鼠炎症牙髓保存治疗后愈合的影响。方法选取24只8周龄雄性SD大鼠上颌磨牙48颗,采用髓腔暴露法穿髓暴露24 h制备牙髓炎症模型,然后切除部分冠髓,根据对牙髓切断后不同的冲洗处理方法分组,2.5%NaClO冲洗(NaClO)组和生理盐水冲洗(NS)组,均以iRoot BP Plus盖髓,窝洞用玻璃离子封闭。两组分别于术后第1、7、28天各处死4只动物,组织病理学观察评估剩余牙髓组织的炎症反应、组织破坏及硬组织的形成情况。结果2.5%NaClO组和NS组的牙髓炎症反应、组织破坏程度和修复性牙本质形成在术后第1、7、28天表现近似,两组间差异无统计学意义。结论在大鼠炎症牙髓模型上牙髓部分切断后运用2.5%NaClO作为iRoot BP Plus盖髓前冲洗止血剂与生理盐水表现出相似的作用,并不影响牙髓炎症的愈合。Objective To evaluate the effect of 2.5%NaClO solution as irrigating agent on the healing of dental pulp after preservation treatment in rats with inflammatory pulp.Methods 48 maxillary molars of 248-week-old male SD rats were selected and pulpitis models were established by pulp cavity exposure for 24 hours.Then part of the crown pulp was removed and divided into two groups according to different irrigation methods:2.5%NaClO flushing group(NaClO)and saline flushing group(NS).The pulp was covered with iRoot BP Plus and the cavity was sealed with glass ionomer.Four animals in the two groups were killed on the 1st,7th and 28th day after operation,respectively.And the inflammatory reaction,tissue destruction and hard tissue formation of residual dental pulp tissue were observed and evaluated by histopathology.Results The pulp inflammatory reaction,tissue destruction and restorative dentin formation in 2.5%NaClO irrigation group and saline irrigation group were similar on the 1st,7th and 28th day after operation,there was no significant difference between the two groups.Conclusion 2.5%NaClO used as a hemostatic before iRoot BP Plus pulp capping after partial pulpotomy has similar effect with normal saline on the inflammatory pulp model of rats,and does not affect the healing of pulp inflammation.

关 键 词：次氯酸钠 活髓保存 牙髓切断 盖髓 

分 类 号：R781.31[医药卫生—口腔医学]