皮内针联合中药治疗肝郁气滞型乳腺癌相关抑郁临床研究  

Clinical Study of Intradermal Needle Therapy Combined with Traditional Chinese Medicine in the Treatment of Breast Cancer-related Depression with Liver Depression and Qi Stagnation Syndrome

作　　者：刘丹 李高飞 邓海燕 LIU Dan;LI Gaofei;DENG Haiyan(Beijing Hospital of Integrated Traditional Chinese and Western Medicine,Beijing 100039,China)

机构地区：[1]北京中西医结合医院,北京100039

出　　处：《辽宁中医药大学学报》2023年第6期92-95,共4页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：北京市中医药科技发展基金项目(JJ2018-29)。

摘　　要：目的 探讨皮内针联合中药汤剂治疗肝郁气滞型乳腺癌相关抑郁的临床疗效。方法 选取2018年4月—2021年12月北京中西医结合医院收治的67例中医辨证属肝郁气滞型乳腺癌伴抑郁症状患者为研究对象,将其按随机数字表法分为对照组35例和治疗组32例。对照组给予常规西药治疗,治疗组予以皮内针联合中药加味逍遥散汤剂治疗,观察并比较两组治疗4周后的治疗有效率、中医证候积分、焦虑及抑郁状态改善情况、血管内皮生长因子(vascular endothelial growth factor,VEGF)和神经生长因子(nerve growth factor,NGF)水平、安全性。结果 治疗4周后,治疗组有效率为96.88%,显著高于对照组的45.71%(P<0.01);对照组中医证候各项积分及总分均无明显变化(P>0.05);治疗组除多梦易醒项证候积分无明显变化外,其他各项积分及总分均显著下降,且均显著低于对照组(P<0.01)。治疗后两组焦虑自评量表(self-rating anxiety scale,SAS)评分、抑郁自评量表(self-rating depression scale,SDS)评分、心理温度计水平均较治疗前下降,且治疗组显著低于对照组(P<0.05);两组卡氏评分(karnofsky performance status,KPS)均较治疗前升高,且治疗组显著高于对照组(P<0.05);两组患者VEGF和NGF水平均显著下降,且治疗组显著低于对照组(P<0.05)。两组在治疗期间均未出现明显不良反应。结论 皮内针联合加味逍遥散汤剂治疗肝郁气滞型乳腺癌相关抑郁疗效显著,不仅可显著提高患者的治疗有效率,还能有效改善其焦虑、抑郁症状及生活质量。与单一西药治疗相比,该中医联合疗法还能有效降低患者VEGF、NGF水平,减少其乳腺癌复发转移可能性,安全性高,值得临床推广应用。Objective To investigate the clinical effect of intradermal needle therapy combined with traditional Chinese medicine decoction in the treatment of breast cancer-related depression with liver depression and Qi stagnation syndrome.Methods A total of 67 breast cancer patients with depressive symptoms of liver depression and Qi stagnation syndrome who were admitted to Beijing hospital of integrated traditional Chinese and Western medicine from April to December 2021 were selected as the research subjects.They were assigned to control group(35 patients)and treatment group(32 patients)by random number table method.Patients in the control group were treated with conventional Western medicine,and those in the treatment group were treated with intradermal needle therapy combined with traditional Chinese medicine Modified Xiaoyao Powder(加味逍遥散).The two groups were compared in terms of the effective rate of treatment,TCM syndrome scores,improvement of anxiety and depression,vascular endothelial growth factor(VEGF)and nerve growth factor(NGF)levels,and safety.Results After 4 weeks of treatment,the effective rate in the treatment group(96.88%)was significantly higher than that in the control group(45.71%)(P<0.01).After 4 weeks of treatment,there was no significant changes in TCM syndrome scores and the total score in the control group(P>0.05).Excepting for deaminess and festless sleep score,the scores for the other TCM syndromes and the total score in the treatment group significantly decreased,and were significantly lower than those in the control group(P<0.01).After 4 weeks of treatment,the SAS scores,SDS scores and psychological thermometer levels in the two groups were decreased,which were significantly lower in the treatment group than in the control group(P<0.05).KPS scores of the two groups increased,and the treatment group had significantly higher scores than the control group(P<0.05).After 4 weeks of treatment,the levels of VEGF and NGF in the two groups significantly decreased,and the levels in the treatme

关 键 词：乳腺癌 抑郁 肝郁气滞型 皮内针 加味逍遥散 中药 

分 类 号：R737.9[医药卫生—肿瘤]