脑小血管病轻度抑郁与脑内红核铁含量相关性研究  

Correlation of mild depression in patients with cerebral small vessel disease and iron content in red nucleus

作　　者：李华[1] 杨华[2] 范雪怡 梁骊 钱海蓉[1,2,3] LI Hua;YANG Hua;FAN Xueyi;LIANG Li;QIAN Hairong(Department of Neurology,the Third Medical Center of PLA General Hospital,Beijing 100089,China;不详)

机构地区：[1]解放军总医院第三医学中心神经内科,北京100089 [2]解放军总医院第六医学中心神经内科,北京100048 [3]华南理工大学医学院,广东广州510641

出　　处：《中华全科医学》2023年第8期1312-1314,1373,共4页Chinese Journal of General Practice

基　　金：首都卫生发展科研专项(首发2020-2-5115)。

摘　　要：目的探究脑小血管病(CSVD)轻度抑郁与红核铁含量之间的关系,评估脑小血管病红核改变对抑郁的预测价值。方法收集2021年5月1日-2022年4月30日就诊于解放军总医院神经内科轻度抑郁CSVD患者41例(试验组)和非抑郁CSVD患者40例(对照组),采用老年抑郁量表(GDS)评定被试者抑郁水平。所有受试者均进行颅脑磁共振磁敏感加权成像扫描,由2名医师测量2组CSVD患者红核感兴趣区(ROI)SWI信号强度值,分析2组CSVD患者红核含铁量,进而探讨轻度抑郁与红核铁含量的相关性。结果轻度抑郁CSVD组患者左侧红核ROI信号强度值(189.36±27.55)较对照组左侧红核ROI信号强度值(213.32±34.33)明显降低(P=0.001);轻度抑郁CSVD组患者平均红核ROI信号强度值(193.06±26.33)较对照组患者平均红核ROI信号强度值(211.64±33.53)明显降低(P=0.007);轻度抑郁CSVD组右侧红核ROI信号强度值较对照组无明显变化;Pearson相关性分析发现平均红核ROI信号强度值、左侧红核ROI信号强度值均与抑郁呈负相关关系。结论脑小血管病轻度抑郁与脑内红核含铁量具有相关性,脑内红核铁含量对脑小血管病轻度抑郁有一定的预测价值。Objective To investigate the relationship between mild depression and iron content in the red nucleus in cerebral small vessel disease(CSVD)patients and evaluated the predictive value of red nucleus in mild depression CSVD patients(control group).Methods Forty-one patients with mildly depressed CSVD(experimental group)and 40 patients with non-depressed CSVD attending the Department of Neurology of the General Hospital of the People's Liberation Army(PLA)from May 1,2021 to April 30,2022 were collected.The depression levels were assessed by the geriatric depression scale(GDS).All subjects underwent magnetic resonance susceptibility weighted imaging scans,the iron content in red nucleus of CSVD patients were semi-quantitatively analyzed using susceptibility weighted imaging(SWI)signal intensity in the region of interest(ROI).The signal intensity in the ROI of the red nucleus was measured by 2 physicians.The iron contents in the red nucleus of the two groups were analyzed and the correlation between mild depression and iron content in the red nucleus of CSVD patients was explored.Results The signal intensity in the left red nucleus ROI(189.36±27.55 vs.213.32±34.33)and the average signal intensity in the red nucleus ROI(193.06±26.33 vs.211.64±33.53)of the mild depression CSVD group were significantly lower than those of the control group(P<0.05),while the signal intensity of the right red nucleus ROI in the mild depression CSVD group were not different from those of the control group.Correlation analysis showed that the mean signal intensity in the red nucleus ROI was negatively correlated with depression,the left signal strength in the red nucleus ROI was negatively correlated with depression.Conclusion Mild depression in CSVD is significantly associated with iron content in the red nucleus,and the content of iron in the red nucleus has a certain value in predicting mild depression of CSVD.

关 键 词：抑郁 脑小血管病 磁敏感加权成像 红核 

分 类 号：R743[医药卫生—神经病学与精神病学] R749.13[医药卫生—临床医学]