血清细胞因子水平与抑郁临床症状相关性研究  

Study on the Correlation between Serum Cytokine Level and Clinical Symptoms of Depression

作　　者：王文文 董继承[2] 赵林 常桂花 李玉娟 王丽丽[3] 高兰 WANG Wenwen;DONG Jicheng;ZHAO Lin;CHANG Guihua;LI Yujuan;WANG Lili;GAO Lan(Qingdao University Medical Department,Qingdao 266000,China;Department of Psychiatry,Qingdao Mental Health Center,Qingdao 266000,China;Department of Psychiatry,Linyi Mental Health Center,Linyi 276000,China)

机构地区：[1]青岛大学医学部,山东青岛266000 [2]青岛市精神卫生中心精神科,山东青岛266000 [3]临沂市精神卫生中心精神科,山东临沂276000

出　　处：《中国医药指南》2023年第21期53-56,共4页Guide of China Medicine

摘　　要：目的探讨血清细胞因子水平变化与抑郁临床症状的相关性。方法选择抑郁发作及复发性抑郁障碍患者43例(病例组),健康人43例(对照组),采用酶联免疫吸附技术(ELISA)测定所有受试者血清中细胞因子水平,对两组进行汉密尔顿抑郁量表-24项(HAMD-24)评估临床症状,分析血清细胞因子IL-1β、IL-2、IL-6、IL-8、IL-10水平与抑郁临床症状的相关性。结果病例组患者IL-2、IL-6、IL-8、IL-10高于对照组(P<0.05)。经Pearson相关性分析发现,抑郁情绪、自杀、入睡困难、工作和兴趣、能力减退感、自卑感、总分与IL-1β、IL-2、IL-6、IL-8、IL-10均无相关关系(P>0.05),精神性焦虑与IL-1β、IL-2、IL-8、IL-10无相关关系(P>0.05),全身症状与IL-1β、IL-2、IL-6、IL-10无相关性关系(P>0.05)。精神性焦虑与IL-6呈负相关关系(P<0.05),全身症状与IL-8呈正相关关系(P<0.05)。当IL-2水平≥0.95 pg/mL、IL-6水平≥3.75 pg/mL、IL-8水平≥13.70 pg/mL、IL-10水平≥0.95 pg/mL时,对诊断预测患病的效能最佳。结论IL-1β对诊断有无患病无预测价值。精神性焦虑与IL-6水平有关;全身症状与IL-8水平有关。当IL-2、IL-6、IL-8、IL-10水平在一定范围内时预测患病的效能最佳。Objective To explore the correlation between the changes of serum cytokines and clinical symptoms of depression.Methods 43 patients with depressive episode and relapsing depressive disorder(case group)and 43 healthy people(control group)were selected.The levels of cytokines in the serum of all subjects were measured by enzyme-linked immunosorbent assay(ELISA),and the clinical symptoms were evaluated by Hamilton Depression Scale-24(HAMD-24),and the serum cytokines IL-1 were analyzedβ,The correlation between the levels of IL-2,IL-6,IL-8 and IL-10 and the clinical symptoms of depression.Results IL-2,IL-6,IL-8 and IL-10 in the case group were higher than those in the control group(P<0.05).Pearson correlation analysis found that depression,suicide,difficulty falling asleep,work and interest,decreased ability,low self-esteem,and total score were not associated with IL-1β,IL-2,IL-6,IL-8,IL-10(P>0.05),and mental anxiety was not associated with IL-1β,IL-2,IL-8,IL-10(P>0.05),systemic symptoms were not associated with IL-1β,IL-2,IL-6,IL-10(P>0.05).Psychiatric anxiety was negatively correlated with IL-6(P<0.05),and systemic symptoms were positively correlated with IL-8(P<0.05).When IL-2 levels≥0.95 pg/mL,IL-6 levels≥3.75 pg/mL,IL-8 levels≥13.70 pg/mL,and IL-10 levels≥0.95 pg/mL,the efficacy is best in diagnosing and predicting disease.Conclusion IL-1βIt has no predictive value for diagnosis.The level of IL-6 was related to psychogenic anxiety;Systemic symptoms are related to the level of IL-8.When the levels of IL-2,IL-6,IL-8 and IL-10 are within a certain range,the prediction of disease is the best.

关 键 词：抑郁障碍 细胞因子 临床症状 评估 

分 类 号：R749.4[医药卫生—神经病学与精神病学]