MRI在高龄首发精神分裂症患者的诊断价值  

The value of MRI in the diagnosis of senile first-episode schizophrenia

作　　者：崔晶晶 王瑞举 孙岚 赵斐 CUI Jingjing;WANG Ruiju;SUN Lan(Radiology Department,Zhengzhou Ninth People's Hospital,Zhengzhou 450053,China)

机构地区：[1]郑州市第九人民医院放射科,郑州450053

出　　处：《国际精神病学杂志》2023年第3期437-440,共4页Journal Of International Psychiatry

摘　　要：目的探讨MRI诊断高龄首发精神分裂症患者的价值。方法将我院2020年9月~2022年7月期间收治的83例高龄首发精神分裂症患者为观察组,同期选取82例健康体检者作为对照组。比较两组脑白质病变参数、脑区病变参数以及脑灰质密度。结果观察组脑室前角间距、体部间距、第三脑室宽距、左右侧裂池宽距、大脑纵裂前半间距低于对照组,三角区域间距高于对照组(P<0.05);观察组左右侧侧脑室面积均大于对照组,距胼胝体下缘水平线长度、距大脑中线长度均长于对照组,穹隆脚中段部位厚度低于对照组,紧贴胼胝体处厚度高于对照组(P<0.05);观察组左右侧尾状核头、左侧小脑前叶、左侧小脑后叶、双侧丘脑灰质密度均低于对照组(P<0.05)。结论将MRI应用于高龄首发精神分裂症患者中,可通过检测其脑白质、脑区病变参数以及脑灰质密度数据变化,以初步评估患者脑部异常,为诊断提供一定依据。Objective To explore the value of MRI in the diagnosis of elderly first-episode schizophrenia.Methods From September 2020 to July 2022,83 elderly first-episode schizophrenics in our hospital were treated as the observation group,and 82 healthy people were selected as the control group at the same time.The parameters of white matter lesions,brain area lesions and gray matter density were compared between the two groups.Results In the observation group,the distance between the anterior horn and the body,the width of the third ventricle,the width of the left and right sylvian cisterns,and the distance between the anterior half of the longitudinal cerebral fissure were lower than those in the control group,and the distance between the trigonal regions was higher than that in the control group(P<0.05).The area of left and right lateral ventricles in the observation group was larger than that in the control group,the length from the horizontal line to the lower margin of the corpus callosum and the length from the midline of the brain were longer than those in the control group,the thickness of the middle segment of the foot of the fornix was lower than that in the control group,and the thickness of the area close to the corpus callosum was higher than that in the control group(P<0.05).The grey matter density of left and right caudate nucleus head,left anterior cerebellar lobe,left posterior cerebellar lobe and bilateral thalamus in the observation group were lower than those in the control group(P<0.05).Conclusion MRI can accurately detect the changes of white matter,brain area lesion parameters and gray matter density data in elderly first-episode schizophrenic patients,so as to preliminarily evaluate the abnormal situation of patients'brain lesions,and provide some evidences for diagnosis of senile first-episode schizophrenia.

关 键 词：磁共振成像 老年 首发精神分裂症 脑形态 

分 类 号：R749.3[医药卫生—神经病学与精神病学]