长链非编码RNA PAPAS与口腔鳞状细胞癌临床病理特征及预后的关系  

Relationship between long chain non-coding RNA PAPAS and clinicopathological characteristics and prognosis of oral squamous cell carcinoma

作　　者：王景涛[1] 娄晓静[1] 孙霞飞 吴亚博 Wang Jingtao;Lou Xiaojing;Sun Xiafei;Wu Yabo(Department of Stomatology,Huaihe Hospital,Henan University,Kaifeng 475000,China)

机构地区：[1]河南大学淮河医院口腔外科,开封475000

出　　处：《中华实验外科杂志》2023年第6期1103-1105,共3页Chinese Journal of Experimental Surgery

摘　　要：目的:探讨长链非编码RNA(lncRNA)PAPAS与口腔鳞状细胞癌临床病理特征及预后的关系。方法:选取2019年12月至2023年3月收治的60例口腔鳞状细胞癌和对应癌旁组织作为研究对象,采用荧光定量聚合酶链反应(PCR)分析癌组织和癌旁组织lncRNA PAPAS表达水平。分析lncRNA PAPAS表达水平与口腔鳞癌患者临床病理特征的关系。并采用Kaplan-Meier分析口腔鳞癌患者3年生存情况,COX回归分析影响口腔鳞癌不良预后发生的危险因素。结果:口腔鳞状细胞癌lncRNA PAPAS表达水平(1.94±0.25)明显高于癌旁组织(1.03±0.12),差异有统计学意义(t=25.940,P<0.05)。低分化患者lncRNA PAPAS表达水平(2.22±0.21)明显高于中高分化患者(1.85±0.16),差异有统计学意义(t=7.632,P<0.05)。淋巴结转移患者lncRNA PAPAS表达水平(2.19±0.24)明显高于未淋巴结转移患者(1.84±0.16),差异有统计学意义(t=6.729,P<0.05)。浸润深度≥5 mm患者lncRNA PAPAS表达水平(2.20±0.20)明显高于未淋巴结转移患者(1.91±0.23),差异有统计学意义(t=4.819,P<0.05)。Ⅲ~Ⅳ期患者lncRNA PAPAS表达水平(2.13±0.22)明显高于Ⅰ~Ⅱ期患者(1.96±0.26),差异有统计学意义(t=2.427,P<0.05)。lncRNA PAPAS高表达组患者3年生存率(37.5%)明显低于低表达组(55.00%),差异有统计学意义(Log-rank=3.145,P<0.05)。淋巴结转移、浸润深度和lncRNA PAPAS表达均是影响口轻鳞状细胞癌患者预后的独立危险因素(P<0.05)。结论:lncRNA PAPAS在口腔鳞癌组织高表达,与肿瘤的浸润深度、淋巴结转移、分化程度和TNM分期有关,其中淋巴结转移、浸润深度和lncRNA PAPAS表达是影响患者预后的独立危险因素。Objective To investigate the relationship between long chain non-coding RNA(lncRNA)PAPAS and clinicopathological features and prognosis of oral squamous cell carcinoma.Methods A total of 60 cases of oral squamous cell carcinoma and corresponding adjacent tissues treated from December 2019 to March 2023 were selected as the research subjects.The expression levels of lncRNA and PAPAS in the cancer tissues and adjacent tissues were analyzed using fluorescence quantitative polymerase chain reaction(PCR).The relationship between the expression level of lncRNA PAPAS and the clinical pathological characteristics of patients with oral squamous cell carcinoma was analyzed.Kaplan Meier was used to analyze the 3-year survival of oral squamous cell carcinoma patients,and COX regression analysis was used to analyze the risk factors that influenced the occurrence of poor prognosis in oral squamous cell carcinoma.Results The expression level of lncRNA PAPAS in oral squamous cell carcinoma(1.94±0.25)was significantly higher than that in adjacent tissues(1.03±0.12)(t=25.940,P<0.05).The expression level of lncRNA PAPAS in patients with low differentiation(2.22±0.21)was significantly higher than that in patients with medium to high differentiation(1.85±0.16)(t=7.632,P<0.05).The expression level of lncRNA PAPAS in patients with lymph node metastasis(2.19±0.24)was significantly higher than that in patients without lymph node metastasis(1.84±0.16)(t=6.729,P<0.05).The expression level of lncRNA PAPAS in patients with infiltration depth≥5 mm(2.20±0.20)was significantly higher than that in patients without lymph node metastasis(1.91±0.23)(t=4.819,P<0.05).The expression level of lncRNA PAPAS in patients with stageⅢ-Ⅳ(2.13±0.22)was significantly higher than that in patients with stageⅠ-Ⅱ(1.96±0.26)(t=2.427,P<0.05).The 3-year survival rate(37.5%)of patients in the lncRNA PAPAS high expression group was significantly lower than that in the low expression group(55.00%)(Log rank=3.145,P<0.05).Lymph node metastasis,invasion

关 键 词：长链非编码RNA PAPAS 口腔鳞状细胞癌 临床病理特征 预后 

分 类 号：R739.8[医药卫生—肿瘤]