成髓细胞瘤转录因子第2亚型和甲状腺激素受体相互作用蛋白6在胃癌组织的表达及其临床意义  

Expression and significance of MYB proto-oncogene like 2 and thyroid receptor interacting protein 6 in gastric cancer tissues

作　　者：陈飞[1] 李双齐[1] 王大勇 谢锐 Chen Fei;Li Shuangqi;Wang Dayong;Xie Rui(Department of General Surgery,Daqing Longnan Hospital(Fifth Affiliated Hospital of Qiqihar Medical College),Daqing 163453,China;Department of Emergency Surgery,Daqing Longnan Hospital(Fifth Affiliated Hospital of Qiqihar Medical College),Daqing 163453,China;Department of Surgery,the First Clinical Medical College of Guangdong Medical University,Zhanjiang 524023,China)

机构地区：[1]大庆市龙南医院(齐齐哈尔医学院第五附属医院)普通外科,大庆163453 [2]广大庆市龙南医院(齐齐哈尔医学院第五附属医院)急诊外科,大庆163453 [3]广东医科大学第一临床医学院外科学系,湛江524023

出　　处：《中华实验外科杂志》2023年第6期1124-1126,共3页Chinese Journal of Experimental Surgery

摘　　要：目的:探讨成髓细胞瘤转录因子第2亚型(MYBL2)和甲状腺激素受体相互作用蛋白6(TRIP6)的表达与胃癌临床病理因素和预后之间的关系。方法:选取大庆市龙南医院(齐齐哈尔医学院第五附属医院)和广东医科大学附属医院2018年11月至2022年11月病理资料完整的105例胃癌组织标本和对应癌旁组织标本,应用免疫组织化学方法检测上述胃癌组织和对应癌旁组织中MYBL2和TRIP6表达水平,采用χ^(2)检验进行相关分析。结果:胃癌组织中MYBL2表达率明显高于对应癌旁组织中MYBL2表达率[74.29%(78/105)比32.38%(34/105)],差异有统计学意义(χ^(2)=37.041,P<0.01)。MYBL2表达水平与胃癌患者TNM分期、淋巴结转移明显相关(χ^(2)=6.881、5.735,P<0.05),MYBL2表达水平与胃癌患者年龄、组织学分化程度、性别无明显相关(χ^(2)=0.008、0.037、0.059,P>0.05)。胃癌组织中TRIP6表达率明显高于对应癌旁组织中TRIP6表达率[66.67%(70/105)比27.62%(29/105)],差异有统计学意义(χ^(2)=32.124,P<0.01)。TRIP6表达水平与胃癌患者组织学分化程度、TNM分期、淋巴结转移明显相关(χ^(2)=4.952、6.983、6.217,P<0.05),TRIP6表达水平与胃癌患者年龄、性别无明显相关(χ^(2)=0.179、0.175,P>0.05)。结论:胃癌组织中MYBL2和TRIP6表达水平升高,MYBL2和TRIP6参与胃癌的发生、发展过程,MYBL2和TRIP6可以作为预测胃癌患者预后的生物学指标。Objective To investigate the expression of MYB proto-oncogene like 2(MYBL2)and thyroid receptor interacting protein 6(TRIP6)in gastric cancer tissues and their correlation with clinicopathological factors and prognosis of gastric cancer.Methods A total of 105 cases of gastric cancer tissues and corresponding adjacent tissues with complete pathological data from November 2018 to November 2022 in Daqing Longnan Hospital(the Fifth Affiliated Hospital of Qiqihar Medical University)and the Affiliated Hospital of Guangdong Medical University were selected.The expression levels of MYBL2 and TRIP6 in the above gastric cancer tissues and corresponding adjacent tissues were detected by immunohistochemistry.Chi-square test was used for correlation analysis.Results The expression rate of MYBL2 in gastric cancer tissues was significantly higher than that in corresponding paracancerous tissues[74.29%(78/105)vs.32.38%(34/105)](χ^(2)=37.041,P<0.01).The expression level of MYBL2 was significantly correlated with TNM stage and lymph node metastasis of gastric cancer patients(respectively,χ^(2)=6.881,5.735,P<0.05).The expression level of MYBL2 was not significantly correlated with age,histological differentiation degree and gender of gastric cancer patients(respectively,χ^(2)=0.008,0.037,0.059,P>0.05).The expression rate of TRIP6 in gastric cancer tissues was significantly higher than that in adjacent tissues[66.67%(70/105)vs.27.62%(29/105)](χ^(2)=32.124,P<0.01).TRIP6 expression level was significantly correlated with histological differentiation,TNM stage and lymph node metastasis of gastric cancer patients(respectively,χ^(2)=4.952,6.983,6.217,P<0.05).TRIP6 expression level was not significantly correlated with age and gender of gastric cancer patients(χ^(2)=0.179,0.175,P>0.05).Conclusion The expression levels of MYBL2 and TRIP6 are increased in gastric cancer tissues.MYBL2 and TRIP6 are involved in the occurrence and development of gastric cancer.MYBL2 and TRIP6 can be used as biological indicators to predict the prognosis

关 键 词：免疫组织化学方法 成髓细胞瘤转录因子第2亚型 甲状腺激素受体相互作用蛋白6 胃癌 

分 类 号：R735.2[医药卫生—肿瘤]