Damon Q自锁托槽正畸治疗疗效及对患者龈沟液氧化应激指标、细胞因子水平的影响  

Curative effect of Damon Q self-locking bracket orthodontic treatment and its effect on oxidative stress indexes and cytokine levels of gingival sulcus liquid

作　　者：陈晔[1] 周玉玲[1] 张念[1] CHEN Ye;ZHOU Yuling;ZHANG Nian(Department of Stomatology,Yuquan Hospital,Tsinghua University,Beijing 100049,China)

机构地区：[1]清华大学玉泉医院口腔科,北京100049

出　　处：《陕西医学杂志》2023年第8期1001-1005,共5页Shaanxi Medical Journal

基　　金：国家自然科学基金资助项目(82205266);北京登峰计划项目(DFL20181501)。

摘　　要：目的:探讨Damon Q自锁托槽正畸治疗疗效及对患者龈沟液氧化应激指标、细胞因子水平的影响。方法:选择接受正畸治疗患者78例为研究对象,按随机数字表法分为结扎托槽组(39例,给予常规结扎式托槽矫治器)和自锁托槽组(39例,给予Damon Q自锁托槽矫治器),统计两组治疗1年后疗效,对比两组治疗前及治疗6个月后的牙周健康指数、龈沟液氧化应激指标、细胞因子水平。结果:治疗1年后,自锁托槽组有效率高于结扎托槽组(P<0.05)。治疗前,两组软垢指数(DI)、牙石指数(CI)、龈沟出血指数(SBI)、牙龈指数(GI)水平比较,差异无统计学意义(均P>0.05);治疗1年后,两组DI、CI、SBI、GI水平均较治疗前升高,与结扎托槽组相比,自锁托槽组DI、CI、SBI、GI水平更低,差异有统计学意义(均P<0.05)。治疗前,两组超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GXH-Px)、丙二醛(MDA)水平比较,差异无统计学意义(均P>0.05);治疗1年后,两组SOD、GXH-Px水平均较治疗前升高,MDA水平降低,与结扎托槽组相比,自锁托槽组SOD、GXH-Px水平更高,MDA水平更低,差异有统计学意义(均P<0.05)。治疗前,两组细胞间黏附分子1(CAM1)、基质金属蛋白酶-2(MMP2)、白介素-1β(IL-1β)、一氧化氮(NO)水平比较,差异无统计学意义(均P>0.05);治疗1年后,两组CAM1、MMP2、NO、IL-1β水平均较治疗前升高,与结扎托槽组相比,自锁托槽组CAM1、MMP2、NO、IL-1β水平较低,差异有统计学意义(均P<0.05)。结论:Damon Q自锁托槽在正畸治疗中疗效显著,能够有效调节龈沟液氧化应激指标,更好地维持口腔卫生,保护牙周组织,对CAM1、MMP2、NO、IL-1β水平影响更小,更有利于牙齿健康。Objective:To investigate the curative effect of Damon Q self-locking bracket orthodontic treatment and its effect on oxidative stress indexes and cytokine levels of gingival sulcus liquid.Methods:Seventy-eight patients receiving orthodontic treatment were selected as the study objects and divided into the ligation bracket group(39 patients receiving conventional ligation bracket appliance)and the self-locking bracket group(39 patients receiving Damon Q self-locking bracket appliance)according to the random number table method.The curative effect of the two groups after 1 year of treatment was analyzed.The periodontal health index,oxidative stress index and cytokine levels of gingival sulcus liquid were compared between the two groups before treatment and 6 months after treatment.Results:After 1 year of treatment,the effective rate of self-locking bracket group was higher than that of ligation bracket group(P<0.05).Before treatment,there were no significant differences in DI,CI,SBI and GI between the two groups(all P>0.05).After 1 year of treatment,the levels of DI,CI,SBI and GI in two groups were higher than those before treatment,and the levels of DI,CI,SBI and GI in the self-locking bracket group were lower than those in the ligation bracket group(all P<0.05).Before treatment,there were no significant differences in the levels of SOD,GXH-Px and MDA between the two groups(all P>0.05).After 1 year of treatment,SOD and GXH-Px levels in both groups were higher than those before treatment,while MDA level was lower;compared with the ligation bracket group,SOD and GXH-Px levels in the self-locking bracket group were higher and MDA level was lower(all P<0.05).Before treatment,there were no significant differences in the levels of CAM1,MMP2,IL-1βand NO between the two groups(all P>0.05).After 1 year of treatment,the levels of CAM1,MMP2,NO and IL-1βin two groups were higher than those before treatment,and the levels of CAM1,MMP2,NO and IL-1βin the self-locking bracket group were lower than those in the ligation bracke

关 键 词：Damon Q自锁托槽 正畸治疗 疗效 牙周健康指数 氧化应激指标 细胞因子 

分 类 号：R783.5[医药卫生—口腔医学]