2015-2018年河南省开封市某区原发性肝癌流行特征  

Epidemiological characteristics of primary liver cancer in a district of Kaifeng of Henan,2015-2018

作　　者：黄昌红[1] 郭青艳[2] 孙冬[1] 陆寒[1] 董聪聪[1] 肖孟迎 李艳玲[1] 闫欣慧 HUANG Changhong;GUO Qingyan;SUN Dong;LU Han;DONG Congcong;XIAO Mengying;LI Yanling;YAN Xinhui(Kaifeng Center for Disease Control and Prevention,Kaifeng,Henan 475000,China;The First Affiliated Hospital of Henan University)

机构地区：[1]开封市疾病预防控制中心,河南开封475000 [2]河南大学第一附属医院

出　　处：《现代疾病预防控制》2023年第7期523-526,共4页MODERN DISEASE CONTROL AND PREVENTION

基　　金：国家科技部“十二五”重大科技专项(2012ZX10002001);开封市科技发展计划项目(1603022)。

摘　　要：目的分析开封市祥符区原发性肝癌(primary hepatocellular carcinoma,PHC)流行特征,为制定PHC免疫预防策略提供依据。方法收集2015-2018年开封市祥符区的PHC病例资料,采集血清样本,开展乙肝表面抗原(HBs Ag)、丙型肝炎抗体(抗-HCV)检测,采用描述性流行病学方法分析PHC流行特征。结果2015-2018年祥符区共收集PHC病例639例,年均发病率20.50/10万;男性470例,发病率为29.33/10万,女性169例,发病率为11.15/10万,发病率男性高于女性(P<0.05),男女性别比为2.78∶1;PHC平均发病年龄为(60.97±11.33)岁,40岁以上614例,占96.09%,80岁以下各年龄组随着年龄增长发病率呈上升趋势(P<0.05),70~79岁年龄组达到峰值(113.20/10万);PHC发病率最高的乡镇为兴隆镇(29.00/10万),最低的为万隆乡(11.32/10万);PHC病例HBs Ag阳性率为66.67%,抗-HCV阳性率为18.15%,HBs Ag和抗-HCV双重阳性率为8.29%;PHC病例乙肝疫苗接种率为8.92%,随着年龄的增长乙肝疫苗接种率呈下降趋势(P<0.05),HBV疫苗及时接种率为0.00%。结论开封市祥符区PHC发病率较高,男性发病率高于女性,80岁以下年龄组发病率随年龄增长而升高,HBV疫苗接种率低且均未及时接种。建议继续采取维持新生儿高水平HBV疫苗及时接种率、HBV母婴阻断及易感人群高水平全程接种率等综合免疫防控措施,实现PHC一级预防。Objective To analyze the epidemiological characteristics of primary hepatocellular carcinoma(PHC)in Xiangfu district of Kaifeng so as to provide evidence for the prevention of PHC immunization.Methods Data of PHC cases in Xiangfu district of Kaifeng from 2015 to 2018 were collected;serum samples were collected;hepatitis B surface antigen(HBsAg)and hepatitis C antibody(anti-HCV)were detected.The epidemiological characteristics of PHC in Xiangfu district were analyzed by descriptive epidemiology.Results A total of 639 cases of PHC were collected in Xiangfu district from 2015 to 2018,with an average annual incidence of 20.50/105.There were 470 males(29.33/105)and 169 females(11.15/105).The male was higher than the female(P<0.05),and the male to female ratio was 2.78:1.The average onset age of PHC was(60.97±11.33)years,and 96.09%(614/639)were over 40 years old.The incidence of PHC in the age groups below 80 years old showed an increasing trend with the increase of age(P<0.05),and the peak reached in 70-79 years old group(113.20/10).The incidence of PHC was highest in Xinglong town(29.00/10)and lowest in Wanlong town(11.32/10).The positive rate of HBsAg in PHC cases was 66.67%;the positive rate of anti-HCV was 18.15%;the dual HBsAg and anti-HCV positive rate was 8.29%.The coverage rate of hepatitis B vaccination in PHC cases was 8.92%;the coverage rate of hepatitis B vaccination decreased with the increase of age(P<0.05),and its timely vaccination rate was 0.00%.Conclusions The incidence of PHC is higher in Xiangfu district of Kaifeng;the incidence in males is higher than that in females;the incidence increases with age before 80 years old.The coverage rate of hepatitis B vaccination is low,and all cases were not vaccinated in time.It is recommended to continue to take comprehensive immunization prevention and control measures such as maintaining a high level of timely hepatitis B vaccination rate among newborns,blocking the mother-to-child transmission of hepatitis B virus and keeping a high level of full vaccinatio

关 键 词：原发性肝癌 发病率 乙型病毒性肝炎表面抗原 抗-HCV 及时接种率 

分 类 号：R575[医药卫生—消化系统]