Metabolic reprogramming of the ovarian cancer microenvironment in the development of antiangiogenic resistance  

作　　者：Huiran Yue Xin Lu 

机构地区：[1]Obstetrics and Gynecology Hospital,Fudan University,Shanghai 200011,China [2]Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases,Shanghai 200011,China

出　　处：《Acta Biochimica et Biophysica Sinica》2023年第6期938-947,共10页生物化学与生物物理学报（英文版）

基　　金：supported by the grants from the National Natural Science Foundation of China(No.82072877).

摘　　要：Antiangiogenic therapies,such as treatment with bevacizumab,display modest survival benefits in ovarian cancer(OC)patients.After a transient response,the upregulation of compensatory proangiogenic pathways and the adoption of alternative vascularization processes lead to the development of resistance.Considering the high mortality rate of Oc,there is an urgent need to uncover the underlying mechanisms of antiangiogenic resistance for the development of novel and effective treatment strategies.Recent investigations have confirmed that metabolic reprogramming in the tumor microenvironment(TME)exerts an essential effect on tumor aggressiveness and angiogenesis.In this review,we provide an overview of the metabolic crosstalk between OC and the TME,high-lighting the regulatory mechanisms underlying the development of antiangiogenic resistance.Metabolic inter-ventions may interrupt this complex and dynamic interactive network,providing a promising therapeutic option to improveclinical outcome in OC patients.

关 键 词：ovarian cancer tumor microenvironment antiangiogenic therapy METABOLISM 

分 类 号：R737.31[医药卫生—肿瘤]