Gas6/Axl在胃肠道恶性肿瘤中的研究进展  

Advancements in investigating Gas6/Axl in gastrointestinal malignant tumors

作　　者：邱振东 邓文宏[1] 王卫星[1,2] QIU Zhendong;DENG Wenhong;WANG Weixing(Department of General Surgery,Renmin Hospital of Wuhan University,Wuhan 430060,P.R.China;Key Laboratory of Hubei Province for Digestive System Disease,Wuhan 430060,P.R.China)

机构地区：[1]武汉大学人民医院普通外科,武汉430060 [2]消化系统疾病湖北省重点实验室,武汉430060

出　　处：《中国普外基础与临床杂志》2023年第7期857-862,共6页Chinese Journal of Bases and Clinics In General Surgery

基　　金：国家自然科学基金面上项目(项目编号:82172855)。

摘　　要：目的了解生长停滞特异性蛋白6/Axl受体酪氨酸激酶(growth arrest specific protein 6/Axl receptor tyrosine kinase,Gas6/Axl)信号通路在胃肠道恶性肿瘤中的研究进展及未来展望。方法检索关于Gas6/Axl信号通路在胃肠道恶性肿瘤中研究的相关文献并进行分析及总结。结果Gas6/Axl信号通路在胃肠道恶性肿瘤中异常上调与活化,导致细胞恶性增殖、侵袭、转移等,从而促进胃肠道恶性肿瘤的发生及发展。目前在胃肠道恶性肿瘤领域中,Gas6/Axl信号通路的研究主要涉及肿瘤血管生成、肿瘤耐药、间质上皮转化及肿瘤微环境。结论Gas6/Axl信号通路调控许多细胞生物过程以及其他下游效应,其异常表达从各个方面促进胃肠道恶性肿瘤的发生与发展。深入探究Gas6/Axl信号通路在胃肠道恶性肿瘤的作用,对寻找治疗胃肠道恶性肿瘤的新靶点具有重要意义。Objective To understand the research progress and future prospects of the growth arrest specific protein 6/Axl receptor tyrosine kinase(Gas6/Axl)signaling pathway in gastrointestinal malignant tumors.Method Retrieve relevant literature on the Gas6/Axl signaling pathway in gastrointestinal malignant tumors and analyze and summarize.Results The Gas6/Axl signaling pathway was abnormally upregulated and activated in gastrointestinal malignancies,leading to malignant cell proliferation,invasion,and metastasis,thereby promoting the occurrence and development of gastrointestinal malignancies.At present,in the field of gastrointestinal cancer,the research of Gas6/Axl signaling pathway mainly involved tumor angiogenesis,tumor drug resistance,mesenchymal epithelial transformation,and tumor microenvironment.Conclusions The Gas6/Axl signaling pathway plays a critical role in governing various cellular processes and downstream effects.Its aberrant expression contributes to the development and advancement of gastrointestinal malignancies through diverse mechanisms.Thoroughly exploring the involvement of the Gas6/Axl signaling pathway in gastrointestinal tumors is of utmost significance,as it holds the potential to unveil novel therapeutic targets for effective management of gastrointestinal malignancies.

关 键 词：受体酪氨酸激酶 生长停滞特异性蛋白6 Axl受体酪氨酸激酶 胃肠道恶性肿瘤 

分 类 号：R735[医药卫生—肿瘤]