叶酸营养状况与宫颈癌发生及病理特征的相关性分析  

Correlation Analysis of Folic Acid Nutritional Status with The Occurrence and Pathological Characteristics of Cervical Cancer

作　　者：张雅莉[1] 刘向娇 张莉[1] 毕胜利[1] ZHANG Ya-li;LIU Xiang-jiao;ZHANG Li;BI Sheng-li(Department of Gynecology,Second Affiliated Hospital of Hebei North University,Zhangjiakou 075100,China)

机构地区：[1]河北北方学院附属第二医院妇科,河北张家口075100

出　　处：《中国食物与营养》2023年第7期62-65,共4页Food and Nutrition in China

摘　　要：目的:探讨叶酸营养状况与宫颈癌发生及术后病理特征的相关性。方法:回顾性收集自2020年2月—2022年9月在本院妇科就诊的81例宫颈癌患者和86例健康体检女性为研究对象。采用健康问卷收集患者年龄、初次性生活年龄、经阴道分娩史、孕次、吸烟、饮酒等一般情况资料,患者住院病历及体检报告收集2组研究对象高危型人乳头瘤病毒(HPV)感染情况,以及宫颈癌患者术后病理信息。收集2组研究对象清晨空腹静脉血检测血清叶酸水平。叶酸营养状况与宫颈癌发生的相关性采用Spearson相关,多因素分析采用Logistic多元回归。结果:与对照组相比,宫颈癌组患者年龄大,初次性生活年龄<23岁、孕次>2次以及高危型HPV感染者的人数多,差异均有统计学意义(P<0.05)。宫颈癌组患者血清平均叶酸水平低于对照组[(6.03±1.87)vs(4.76±1.49)ng/mL,P=0.011],宫颈癌患者血清叶酸水平≤3.1 ng/mL人数高于对照组[(19/62)vs(5/81),P=0.009],且血清叶酸水平与宫颈癌的发生呈显著负相关(r=-0.518,P<0.05)。年龄、初次性生活年龄≥23岁、感染高危型HPV及叶酸水平≤3.1 ng/mL是宫颈癌发生的危险因素,均有OR>1、P<0.05。宫颈癌患者血清叶酸水平≤3.1 ng/mL与淋巴结转移(r=-0.437)、临床分期相关(r=-0.408),均有P<0.05。结论:叶酸营养状况与宫颈癌的发生及术后较差的病理特征呈负相关,且血清叶酸水平≤3.1 ng/mL是发生宫颈癌的危险因素。女性应关注叶酸营养状况,注意叶酸补充,以预防宫颈癌的发生发展。Objective To investigate the correlation between folic acid nutritional status and cervical carcinogenesis and postoperative pathological features.Method We retrospectively collected 81 patients with cervical cancer and 86 women with health checkups who attended our gynecology department from February 2020 to September 2022 as study subjects.Health questionnaires were used to collect general information on patients'age,age at first sex,history of transvaginal delivery,number of pregnancies,smoking and alcohol consumption,and information on high-risk human papilloma virus(HPV)infection and postoperative pathology of cervical cancer patients in both study groups were collected from patients′inpatient medical records and physical examination reports.Early morning fasting venous blood was collected for serum folate levels in both study groups.The correlation between folic acid nutritional status and cervical carcinogenesis was performed using Spearson correlation,and logistic multiple regression was used for multifactorial analysis.Result There was a statistically significant difference(P<0.05)in the number of patients in the cervical cancer group who were older,had their first sexual intercourse at<23 years of age,had>2 pregnancies,and had high-risk HPV infection compared with the control group.The mean serum folate level was lower in the cervical cancer group than in the control group[(6.03±1.87)vs(4.76±1.49)ng/mL,P=0.011],and the number of patients with serum folate level≤3.1 ng/mL was higher in the cervical cancer group than in the control group[(19/62)vs(5/81),P=0.009],and there was a significant negative correlation between serum folate level and the occurrence of cervical cancer(r=-0.518,P<0.05).Age,age at first sex≥23 years,infection with high-risk HPV and folic acid level≤3.1 ng/mL were risk factors for the development of cervical cancer,all with OR>1,P<0.05.Serum folic acid level≤3.1 ng/mL was associated with lymph node metastasis(r=-0.437)and clinical stage(r=-0.408)in patients with cervical ca

关 键 词：叶酸 宫颈癌 病理特征 危险因素 

分 类 号：R737.33[医药卫生—肿瘤]