Cartilage-targeting and inflammatory-responsive nanocarriers for effective osteoarthritis treatment via reactive oxygen species scavenging and anti-angiogenesis  

作　　者：Sixiang Wang Yan Gao Lili Dong Peixing Chen Wanqian Liu Li Yang 

机构地区：[1]National Innovation and Attracting Talents“111”base,Key Laboratory of Biorheological Science and Technology,Ministry of Education,Collegeof Bioengineering,Chongqing University,Chongqing 400030,China [2]Department of Orthopaedics,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400042,China [3]Chongqing Key Laboratory of Nano/Micro Composite Material and Device,School of Metallurgy and Materials Engineering,Chongqing University of Science and Technology,Chongqing 401331,China

出　　处：《Journal of Materials Science & Technology》2023年第12期30-42,共13页材料科学技术（英文版）

基　　金：financially supported by the National Natural Science Foundation of China (Nos.11532004 and 11832008);the Innovation and Attracting Talents Program for College and Univer-sity (“111”Project) (No.B06023).

摘　　要：Osteoarthritis(OA),a common disabling joint disease,is highly associated with microenvironmental changes in the cartilage and subchondral bone.Elevated reactive oxygen species(ROS)in the cartilage and subchondral bone angiogenesis accelerate articular cartilage erosion.New cartilage-targeting drug deliv-ery systems that are aimed at preventing ROS production and angiogenesis may be of clinical significance for OA treatment.Herein,an ROS scavenger and an inflammatory-responsive nanocarrier are designed by immobilizing the natural polyphenol(curcumin)in chitosan-catechol nanoformulations(Cur-CS-C NPs)via boronate ester.The robust cartilage-targeting effects and ROS scavenging capacities of Cur-CS-C NPs were respectively determined in cartilage explants and chondrocytes.Intra-articular injection of Cur-CS-C NPs in OA rat models efficiently suppressed angiogenesis and cartilage degradation partially via the ROS-mediated NF-κB/PI3K-Akt signaling pathway.The developed curcumin-functionalized nanocarriers can significantly delay OA progression and provide a promising therapeutic strategy for other inflamma-tory diseases that are characterized by oxidative stress and angiogenesis.

关 键 词：OSTEOARTHRITIS Reactive oxygen species Angiogenesis Cartilage-targeting Drug delivery systems Chitosan-catechol nanocarriers 

分 类 号：R318.08[医药卫生—生物医学工程] TB383.1[医药卫生—基础医学]