逆转录转座子LINE-1介导配子和胚胎发育异常的研究进展  

Research progress of retrotransposon LINE-1 mediating abnormal gamete and embryo development

作　　者：平昀鹭 赵小萱 冯晓玲[2] Ping Yunlu;Zhao Xiaoxuan;Feng Xiaoling(Graduate School of Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China;The Second Department of Gynaecology of the First Affiliated Hospital,Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学研究生院,哈尔滨150040 [2]黑龙江中医药大学附属第一医院妇科二科,哈尔滨150040

出　　处：《中华生殖与避孕杂志》2023年第7期757-762,共6页Chinese Journal of Reproduction and Contraception

基　　金：国家自然科学基金面上项目(81973894,82174421)。

摘　　要：长散布核元件-1(long interspersed nuclear element-1,LINE-1)是人类基因组中唯一自主转座的非末端重复序列逆转录转座子,能够复制并粘贴到基因组的新位点。为了确保进化成功,可遗传的新LINE-1插入物在携带遗传信息的生殖细胞和胚胎干细胞中积累。然而,早期胚胎发育中LINE-1抑制的减少可能会导致反转座子插入引起基因组突变,LINE-1 mRNA和蛋白质表达增加可能通过诱导胎儿卵母细胞消耗、DNA损伤与免疫炎症反应间接造成早期胚胎损伤乃至妊娠丢失。本文总结并分析了近年来关于LINE-1表观调控在配子发生及早期胚胎发育过程中的作用及其诱发早期自然流产的研究进展。Long interspersed nuclear element-1(LINE-1)is the only self-transposable non-terminal repeat retrotransposon in the human genome,which can copy and paste to new sites in the genome.To ensure evolutionary success,heritable new LINE-1 inserts accumulate in germ cells and embryonic stem cells,which carry genetic information.However,the reduction of LINE-1 inhibition in early embryo development may lead to genomic mutations induced by reverse transposon insertion.Increased LINE-1 mRNA and protein expression may indirectly cause early embryo damage or even pregnancy loss by inducing oocyte wear,DNA damage and immune inflammatory response.This paper summarized and analyzed the research progress on the role of LINE-1 epigenetic regulation in gametogenesis and early embryo development and the causes of early pregnancy loss.

关 键 词：胚胎发育 配子发生 逆转录转座子 长散布核元件-1 早期自然流产 

分 类 号：R394[医药卫生—医学遗传学]