RGD肽类示踪剂及其PET显像在脑胶质瘤诊疗中的应用  

RGD peptide tracers and their PET imaging in the diagnosis and treatment of glioma

作　　者：潘越 王观筠 党浩丹[2] 徐白萱[2] Pan Yue;Wang Guanyun;Dang Haodan;Xu Baixuan(Graduate School of Chinese PLA Medical College,Beijing 100853,China;Department of Nuclear Medicine,the First Medical Center,Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军医学院研究生院,北京100853 [2]解放军总医院第一医学中心核医学科,北京100853

出　　处：《国际放射医学核医学杂志》2023年第6期362-366,共5页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金(82001859)。

摘　　要：细胞黏附因子整合素αvβ3在包括脑胶质瘤在内的多种肿瘤新生血管内皮细胞及细胞表面高表达, 而在正常细胞表面低表达或不表达。精氨酸-甘氨酸-天冬氨酸(RGD)肽可特异性结合整合素αvβ3。放射性核素标记的RGD肽已成为脑胶质瘤靶向显像的研究热点, RGD PET显像在脑胶质瘤诊断和疗效监测中有一定的价值。基于此, 笔者对RGD PET显像在脑胶质瘤诊疗中的应用进行综述。Cell adhesion factor integrinαvβ3 is highly expressed in the surface of neovascularization endothelial cells and cells of many kinds of tumors,including gliomas,while it is low or not expressed in the surface of normal cells.Arginine-glycine-aspartic acid(RGD)peptides can specifically bind to integrinαvβ3.Radionuclide-labeled RGD peptide has become the research focus of targeted imaging of glioma.RGD PET imaging has certain value in the diagnosis and curative effect monitoring of glioma.Based on this,this article reviews the application of RGD PET imaging in the diagnosis and treatment of glioma.

关 键 词：脑肿瘤 神经胶质瘤 整合素ΑVΒ3 正电子发射断层显像术 精氨酸-甘氨酸-天冬氨酸 

分 类 号：R739.41[医药卫生—肿瘤]