核医学显像在心脏淀粉样变性中的应用进展  

Application progress of nuclear medicine imaging in cardiac amyloidosis

作　　者：张元丽 李慧敏 郭小闪[1] Zhang Yuanli;Li Huimin;Guo Xiaoshan(Department of Nuclear Medicine,the First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一医院核医学科,太原030001

出　　处：《国际放射医学核医学杂志》2023年第6期372-377,共6页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：淀粉样变性是由多种原因造成的淀粉样物质在体内各脏器细胞间的沉积, 其可使受累脏器的功能逐渐衰竭。淀粉样物质累及心脏时即导致心脏淀粉样变性(CA), 其预后最差。CA中以转甲状腺素蛋白淀粉样变性型及免疫球蛋白轻链型最常见, 二者的中位生存期及治疗方法存在巨大差异, 因此, 早期诊断及准确分型对于患者的治疗至关重要。核医学显像可以对CA患者进行无创性诊断及准确分型, 在临床上逐渐得到了广泛应用。笔者就核医学显像在CA中的最新研究进展作一综述, 以提高临床医师对于CA的认识, 便于早期诊断CA。Amyloidosis is the accumulation of amyloid in the cells of various organs in the body caused by various reasons,resulting in the gradual failure of the affected organs.When amyloid affects the heart,known as cardiac amyloidosis(CA),the prognosis is the worst.In CA,transthyretin amyloidosis and immunoglobulin light chain amyloidosis are the most common,and there are huge differences in the median survival time and treatment methods of the two.Therefore,early diagnosis and accurate classification are crucial for the treatment of such patients.Nuclear medicine imaging can non-invasively diagnose and accurately classify CA,and has been widely used in clinical practice.This article reviews the recent progress of nuclear medicine imaging in CA to improve clinicians'understanding of CA and facilitate early diagnosis of CA.

关 键 词：淀粉样变性 前白蛋白 免疫球蛋白轻链 体层摄影术 发射型计算机 单光子 正电子发射断层显像术 体层摄影术 X线计算机 

分 类 号：R817.4[医药卫生—影像医学与核医学] R541[医药卫生—放射医学]