Impact of bariatric surgery on glucose and lipid metabolism and liver and kidney function in food-induced obese diabetic rats  

作　　者：Hong Long Lei Zhao Zhong-Sheng Xiao Shu-Xiang Li Qiu-Lin Huang Shuai Xiao Liang-Liang Wu 

机构地区：[1]Department of Gastrointestinal Surgery,The First Affiliated Hospital,Hengyang Medical School,University of South China,Hengyang 421001,Hunan Province,China

出　　处：《World Journal of Diabetes》2023年第8期1249-1258,共10页世界糖尿病杂志（英文版）（电子版）

基　　金：the Natural Science Foundation of Hunan Province,No.2021JJ70119.

摘　　要：BACKGROUND Obesity usually causes diabetes mellitus(DM)and is a serious danger to human health.Type 2 DM(T2DM)mostly occurs along with obesity.Foodborne obesityinduced DM is caused by an excessive long-term diet and surplus energy.Bariatric surgery can improve the symptoms of T2DM in some obese patients.But different types of bariatric surgery may have different effects.AIM To investigate the effect of bariatric surgery on glucose and lipid metabolism and liver and kidney function in rats.METHODS Male Sprague-Dawley rats aged 6-8 wk underwent Roux-en-Y gastric bypass surgery(RYGB),sleeve gastrectomy(SG),or gastric banding(GB).Glucose and insulin tolerance tests,analyses of biochemical parameters,histological examination,western blot,and quantitative real-time polymerase chain reaction were conducted.RESULTS In comparison to the sham operation group,the RYGB,SG,and GB groups had decreased body weight and food intake,reduced glucose intolerance and insulin insensitivity,downregulated biochemical parameters,alleviated morphological changes in the liver and kidneys,and decreased levels of protein kinase Cβ/P66shc.The effect in the RYGB group was better than that in the SG and GB groups.CONCLUSION These results suggest that RYGB,SG and GB may be helpful for the treatment of foodborne obesity-induced DM.

关 键 词：Diabetes mellitus OBESITY Bariatric surgeries Liver and kidney function 

分 类 号：R587.1[医药卫生—内分泌]