Prognostic role of metformin in diabetes mellitus type 2 patients with hepatocellular carcinoma:A systematic review and meta-analysis  

作　　者：Maja Cigrovski Berkovic Francesco Giovanardi Anna Mrzljak Quirino Lai 

机构地区：[1]Department of Kinesiological Anthropology and Methodology,Faculty of Kinesiology,University of Zagreb,Zagreb 10000,Croatia [2]General Surgery and Organ Transplantation Unit,Department of Surgery,Sapienza University of Rome,Rome 00018,Italy [3]Department of Gastroenterology and Hepatology,University Hospital Center Zagreb,Zagreb 10000,Croatia [4]Department of Medicine,School of Medicine,Zagreb 10000,Croatia

出　　处：《World Journal of Diabetes》2023年第8期1289-1300,共12页世界糖尿病杂志（英文版）（电子版）

摘　　要：BACKGROUND Hepatocellular carcinoma(HCC)is among the commonest malignancies associated with significant cancer-related death.The identification of chemopreventive agents following HCC treatments with the potential to lower the risk of HCC adverse course is intriguing.Metformin,a first-line agent used in the treatment of type 2 diabetes mellitus(T2DM),has been associated with inhibition of HCC growth.AIM To determine whether metformin can prevent adverse events(i.e.,death,tumor progression,and recurrence)after any HCC treatment in T2DM patients.METHODS A systematic review of the published literature was undertaken focused on the role of metformin on outcomes in patients with T2DM and HCC receiving any tumor therapy.A search of the PubMed and Cochrane Central Register of Controlled Trials Databases was conducted.RESULTS A total of 13 studies(n=14886 patients)were included in this review.With regard to the risk of death,a decreased risk was reported in cases receiving metformin,although this decrease was not statistically significant[odds ratio(OR)=0.89,P=0.42].When only patients treated with curative strategies were considered,a more marked correlation between metformin and favorable cases was reported(OR=0.70,P=0.068).When analyzing palliative treatment,there was no statistical significance in terms of the correlation between metformin and favorable cases(OR=0.74,P=0.66).As for the risks of progressive disease and recurrence,no obvious correlation between metformin use and reduced risk was reported.When sub-analyses were performed for patients from different regions,the results for patients from Eastern countries showed a tendency for decreased risk of death in T2DM cases receiving metformin(OR=0.69,P=0.17),but the same was not seen in patients from Western countries(OR=1.19,P=0.31).CONCLUSION Metformin failed to show a marked impact in preventing adverse effects after HCC treatment.A trend was reported in T2DM cases receiving curative therapies in relation to the risk of death,especially in patients from Eastern

关 键 词：Hepatocellular carcinoma METFORMIN Type 2 diabetes mellitus DEATH RECURRENCE Progression Treatment 

分 类 号：R587.1[医药卫生—内分泌] R735.7[医药卫生—内科学]