Neuroendocrine carcinoma of the endometrium concomitant with Lynch syndrome:A case report  

作　　者：Wing Yu Sharon Siu Mun-Kun Hong Dah-Ching Ding 

机构地区：[1]Department of Obstetrics and Gynecology,Hualien Tzu Chi Hospital,Hualien 970,Taiwan,China [2]Minimally Invasive Gynecology Surgery Center,Department of Obstetrics and Gynecology,Hualien Tzu Chi Hospital,Hualien 970,Taiwan,China [3]Department of Obstetrics and Gynecology,Hualien Tzu Chi Hospital,Tzu Ch University,Hualien 970,Taiwan,China

出　　处：《World Journal of Clinical Cases》2023年第21期5160-5166,共7页世界临床病例杂志

摘　　要：BACKGROUND Large-cell neuroendocrine carcinoma(NEC)is an uncommon type of tumor that can occur in the endometrium.This aggressive cancer requires definitive management.Here,we describe the clinical characteristics and treatment of a postmenopausal woman with large cell NEC of the endometrium.CASE SUMMARY A 55-year-old Asian female presented with a 1-year history of postmenopausal vaginal bleeding.Transvaginal ultrasound revealed a thickened endometrium(30.2 mm)and a hypervascular tumor.Computed tomography revealed that the tumor had invaded more than half of the myometrium and spread to the pelvic lymph nodes.The tumor marker,carcinoembryonic antigen,was elevated(3.65 ng/mL).Endocervical biopsy revealed high-grade endometrial carcinoma.She underwent radical hysterectomy,bilateral salpingo-oophorectomy,omentectomy,and bilateral pelvic and para-aortic lymph node dissection.Pathological examination revealed mixed neuroendocrine and endometrioid adenocarcinoma,pT2N0M0,grade 3,and International Federation of Gynecology and Obstetrics stage 2.Immunohistochemistry showed moderate estrogen and progesterone receptor expressions(20%and 1%,respectively),focal CD56 expression(NEC marker),positive staining for vimentin,p53(wild type),and ki67(90%),and loss of expression of PMS2(Lynch syndrome marker).The patient received five cycles of cisplatin and etoposide after surgery.No recurrence was noted after 5 mo.CONCLUSION We report the characteristics and successful management of a rare case of large cell endometrial NEC concomitant with Lynch syndrome.

关 键 词：Neuroendocrine carcinoma ENDOMETRIUM Large cell carcinoma IMMUNOHISTOCHEMISTRY Lynch syndrome Case report 

分 类 号：R737.33[医药卫生—肿瘤]