Changes in neurotransmitter levels,brain structural characteristics,and their correlation with PANSS scores in patients with firstepisode schizophrenia  

作　　者：Xian-Jia Xu Tang-Long Liu Liang He Ben Pu 

机构地区：[1]The Fifth Ward,Ningbo Psychiatric Hospital,Ningbo 315000,Zhejiang Province,China [2]Department of Science and Education,Ningbo Psychiatric Hospital,Ningbo 315000,Zhejiang Province,China [3]The Sixteenth Ward,Ningbo Psychiatric Hospital,Ningbo 315000,Zhejiang Province,China [4]The Twelfth Ward,Ningbo Psychiatric Hospital,Ningbo 315000,Zhejiang Province,China

出　　处：《World Journal of Clinical Cases》2023年第22期5215-5223,共9页世界临床病例杂志

摘　　要：BACKGROUND In patients with schizophrenia,the brain structure and neurotransmitter levels change,which may be related to the occurrence and progression of this disease.AIM To explore the relationships between changes in neurotransmitters,brain structural characteristics,and the scores of the Positive and Negative Symptom Scale(PANSS)in patients with first-episode schizophrenia.METHODS The case group comprised 97 patients with schizophrenia,who were evaluated using the Canadian Neurological Scale and confirmed by laboratory tests at Ningbo Mental Hospital from January 2020 to July 2022.The control group comprised 100 healthy participants.For all participants,brain structural characteristics were explored by measuring brain dopamine(DA),glutamic acid(Glu),and gamma-aminobutyric acid(GABA)levels,with magnetic resonance imaging.The case group was divided into negative and positive symptom subgroups using PANSS scores for hierarchical analysis.Linear correlation analysis was used to analyze the correlations between neurotransmitters,brain structural character istics,and PANSS scores.RESULTS Patients in the case group had higher levels of DA and lower levels of Glu and GABA,greater vertical and horizontal distances between the corpus callosum and the inferior part of the fornix and larger ventricle area than patients in the control group(P<0.05).Patients with positive schizophrenia symptoms had significantly higher levels of DA,Glu,and GABA than those with negative symptoms(P<0.05).In patients with positive schizophrenia symptoms,PANSS score was significantly positively correlated with DA,vertical and horizontal distances between the corpus callosum and the infrafornix,and ventricular area,and was significantly negatively correlated with Glu and GABA(P<0.05).In patients with negative schizophrenia symptoms,PANSS score was significantly positively correlated with DA,vertical distance between the corpus callosum and the infrafornix,horizontal distance between the corpus callosum and the infrafornix,and ventricular area,a

关 键 词：Brain structural characteristics Negative symptoms Neurotransmitters positive symptoms SCHIZOPHRENIA 

分 类 号：R749.3[医药卫生—神经病学与精神病学]