Diabetic neuropathy results in vasomotor dysfunction of medium sized peripheral arteries  

作　　者：Fahrettin Ege Ömer Kazci Sonay Aydin 

机构地区：[1]Department of Neurology,VM Medicalpark Hospital,Ankara 063200,Turkey [2]Department of Radiology,Ankara Training and Research Hospital,Ankara 063200,Turkey [3]Department of Radiology,Erzincan Binali Yıldırım University Faculty of Medicine,Erzincan 063200,Turkey

出　　处：《World Journal of Clinical Cases》2023年第22期5244-5251,共8页世界临床病例杂志

摘　　要：BACKGROUND The effect of the sympathetic nervous system on peripheral arteries causes vasoconstriction when smooth muscle cells in the walls of blood vessels contract,which leads to narrowing of arteries and reduction of the blood flow.AIM To compare sympathetic vasomotor activation of the brachial arteries in healthy subjects and patients with painful diabetic neuropathy;and therefore,to assess whether there is significant vasomotor dysfunction of medium sized arteries in diabetic neuropathy.METHODS The study included 41 diabetic neuropathy patients and 41 healthy controls.Baseline diameter and flow rate of the brachial arteries were measured.Then,using a bipolar stimulus electrode,a 10 mA,1 Hz electrical stimulus was administered to the median nerve at the wrist level for 5 s.The brachial artery diameter and blood flow rate were re-measured after stimulation.RESULTS In the control group,the median flow rate was 70.0 mL/min prior to stimulation and 35.0 mL/min after stimulation,with a statistically significant decrease(P<0.001),which is consistent with sympathetic nervous system functioning(vasoconstriction).In the diabetic neuropathy group,median flow rate before the stimulation was 35.0 mL/min.After stimulation,the median flow rate was 77.0 mL/min;thus,no significant decrease in the flow rate was detected.In the control group,the median brachial artery diameter,which was 3.6 mm prior to stimulation,decreased to 3.4 mm after stimulation,and this decrease was also statistically significant(P=0.046).In the diabetic neuropathy group,the median brachial artery diameter increased from 3.4 mm to 3.6 mm following nerve stimulation.Once again,no narrowing was observed.CONCLUSION Our research suggests that diabetic neuropathy results in significant vasomotor dysfunction of medium sized peripheral arteries.Physiological vasoconstriction in response to sympathetic activation is impaired in diabetic neuropathy.

关 键 词：Diabetic neuropathy VASOMOTOR DYSFUNCTION Peripheral arteries Doppler ultrasound 

分 类 号：R587.2[医药卫生—内分泌]