Differences in metabolic improvement after metabolic surgery are linked to the gut microbiota in non-obese diabetic rats  

作　　者：Xin Luo Cai Tan Fang Tao Chi-Ying Xu Zhi-Hua Zheng Qiang Pang Xiang-An He Jia-Qing Cao Jin-Yuan Duan 

机构地区：[1]Department of General Surgery,The First Affiliated Hospital of Nanchang University,Nanchang 330000,Jiangxi Province,China [2]Department of Women’s Health,Jiangxi Maternal and Child Health Hospital,Nanchang 330006,Jiangxi Province,China [3]Department of General Surgery,The Second Affiliated Hospital of Nanchang University,Nanchang 330000,Jiangxi Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2023年第7期1304-1316,共13页世界胃肠外科杂志（英文版）（电子版）

基　　金：the National Natural Science Foundation of China,No.81760156,81960154 and 82060161;the Natural Science Foundation of Jiangxi Province,No.2018ACB21040,20203BBGL73185,and 20212BAB206020;Foundation of Health commission of Jiangxi Province,No.SKJP220225830。

摘　　要：BACKGROUND Different metabolic/bariatric surgery approaches vary in their effect on weight loss and glucose levels,although the underlying mechanism is unclear.Studies have demonstrated that the gut microbiota might be an important mechanism of improved metabolism after metabolic/bariatric surgery.AIM To investigate the relationship between the improvement in metabolic disturbances and the changes in gut microbiota after gastric or intestinal bypass.METHODS We performed sleeve gastrectomy(SG),distal small intestine bypass(DSIB)or sham surgery in nonobese rats with diabetes induced by 60 mg/kg streptozotocin(STZ-DM).RESULTS The group comparisons revealed that both SG and DSIB induced a reduction in body weight and significant improvements in glucose and lipid metabolism in the STZ-DM rats.Furthermore,DSIB exhibited a stronger glucose-lowering and lipidreducing effect on STZ-DM rats than SG.16S ribosomal RNA gene sequencing revealed the gut abundance of some Lactobacillus spp.increased in both the SG and DSIB groups after surgery.However,the DSIB group exhibited a more pronounced increase in the gut abundance of Lactobacillus spp.compared to the SG group,with more Lactobacillus spp.types increased in the gut.CONCLUSION The gut abundance of Lactobacillus was significantly correlated with the improvement in glycolipid metabolism and the change in serum fibroblast growth factor 21 levels.

关 键 词：Diabetes Glucose control Lipid metabolism MICROBIOTA Obesity GASTRECTOMY Distal small intestine bypass 

分 类 号：R574[医药卫生—消化系统]