Cavefish mount a rapid and sustained regenerative response following skeletal muscle injury  

作　　者：Luke Olsen Huzaifa Hassan Fanning Xia Sarah Keaton Nicolas Rohner 

机构地区：[1]Stowers Institute for Medical Research,Kansas City,MO 64110,USA [2]Department of Molecular&Integrative Physiology,University of Kansas Medical Center,Kansas City,KS 66160,USA [3]Department of Biological Sciences,DePaul University,Chicago,IL 60614,USA

出　　处：《Zoological Research》2023年第4期776-778,共3页动物学研究（英文）

基　　金：supported by institutional funding from the Stowers Institute for Medical Research,NIH Grant 1DP2AG071466-01,NIH Grant R01 GM127872,NSF IOS-1933428;NSF EDGE Award 1923372。

摘　　要：Dear Editor,Physical injury and tissue damage are prevalent throughout the animal kingdom,with the ability to regenerate quickly and efficiently providing a selective advantage.In most vertebrates,skeletal muscle possesses a remarkable ability to regenerate,making it a valuable model for investigating the cellular processes underpinning tissue regeneration.Following damage,skeletal muscle mounts a complex regenerative cascade centered around dedicated muscle stem cells,i.e.,satellite cells.These satellite cells are,in turn,regulated by both resident and infiltrating innate immune cells of myeloid lineage,which play a crucial role in activating and guiding the transition of satellite cells towards maturation(Chen et al.,2020;Tidball,2017;Tidball&Villalta,2010).While critical for muscle regeneration,the innate immune system is energetically costly,resulting in many species decreasing immune investment under nutrient-limited environments.Whether this reduced investment results in a decreased capacity to mount a regenerative response following tissue damage remains unclear.Here,we utilized an emerging evolutionary model,the Mexican tetra(Astyanax mexicanus),to investigate the consequences of shifts in immune system investment on skeletal muscle regeneration.

关 键 词：SUSTAINED MOUNT INJURY 

分 类 号：Q418[生物学—生理学]