外泌体对细胞铁死亡调控的研究进展  

Research progress in the regulation of exosomes on cell Ferroptosis

作　　者：赵晟 王国栋[2] 姜佳汶 孙兆丰 翟传兴 张元民[2] Zhao Sheng;Wang Guodong;Jiang Jiawen;Sun Zhaofeng;Zhai Chuanxing;Zhang Yuanmin(School of Clinical Medicine,Jining Medical University,Jining 272067,China;Department of Joint Surgery and Sports Medicine,Affiliated Hospital of Jining Medical University,Jining 272029,China;School of Clinical Medicine,Weifang Medical University,Weifang 261041,China)

机构地区：[1]济宁医学院临床医学院,济宁272067 [2]济宁医学院附属医院骨关节外科,济宁272067 [3]潍坊医学院临床医学院,潍坊261041

出　　处：《中国医师杂志》2023年第7期1105-1109,共5页Journal of Chinese Physician

基　　金：国家自然科学基金(81871814);济宁市重点研发计划(2020YXNS022)。

摘　　要：铁死亡是一种铁依赖性的非凋亡性细胞死亡,由大量脂质过氧化介导的细胞膜损伤引起。最近的证据表明,外泌体作为一种直径为30~100 nm的囊泡小体,其中包含的蛋白质、各种RNA和脂类等多种活性成分可通过调控细胞铁死亡从而影响相关疾病的诊断及治疗。为此本文阐述外泌体在细胞铁死亡调控中的研究意义,分析其对疾病治疗的作用,并回顾近年来有关外泌体调控细胞铁死亡的相关报道和研究。Ferroptosis is an iron-dependent,apoptotic cell death caused by massive lipid peroxidation-mediated cell membrane damage.Recent evidence suggests that exosomes,as a 30-100 nm diameter follicular body,contain a variety of active ingredients such as proteins,various RNAs and lipids that can have a great impact on the diagnosis and treatment of related diseases by regulating cellular iron death.To this end,this paper elaborates the research significance of exosomes in the regulation of cell ferroptosis,analyzes their role in disease treatment,and reviews the relevant reports and studies on exosomes regulating cell ferroptosis in recent years.

关 键 词：外泌体 铁死亡 脂质过氧化作用 肿瘤 

分 类 号：R363[医药卫生—病理学]