阿尔茨海默病重复经颅磁刺激治疗的研究进展  

Research progress on repetitive transcranial magnetic stimulation in treatment of Alzheimer's disease

作　　者：林亚可 孙婷婷[1] 黄亚楠(综述) 潘永惠(审校)[1] LIN Yake;SUN Tingting;HUANG Yanan(Department of Neurology,The First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院神经内科,黑龙江哈尔滨150001

出　　处：《中风与神经疾病杂志》2023年第7期601-605,共5页Journal of Apoplexy and Nervous Diseases

基　　金：国家自然科学基金项目(82071549);黑龙江省自然科学基金重点项目(ZD2019H006);黑龙江省教育科学“十三五”规划重点课题(GJB1319086)。

摘　　要：阿尔茨海默病(Alzheimer's disease,AD)是一种起病隐匿且进行性发展的慢性神经系统退行性疾病,以记忆障碍、语言功能障碍为主要症状。目前AD发病机制尚不明确,药物治疗AD尚未取得良好效果,这迫使我们寻找治疗AD的新方法。现有研究表明重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)治疗可以改善AD患者的认知能力、神经精神症状等临床表现,这为AD患者的治疗提供了新的思路。探索其改善AD患者临床表现背后的机制,也有助于我们进一步了解AD的发病机制。本文整理了AD患者的病理变化及临床表现特点,同时总结rTMS治疗AD的研究进展,以期为探索AD的发病机制及治疗提供新思路。Alzheimer's disease(AD)is a chronic neurodegenerative disease that occurs insidiously and progresses over time.Its main symptoms include memory and language impairments.The pathogenesis of AD remains unclear,and drug treatment for AD is still unsatisfactory,pointing to the need for a new approach to treating this disease.Existing research has shown that repetitive transcranial magnetic stimulation(rTMS)can improve the cognitive and neuropsychiatric symptoms of patients with AD,which provides a new idea for the treatment of AD.Exploring the mechanism of rTMS improving the clinical manifestations of patients with AD can promote our understand of the pathogenesis of AD.This article summarized the pathological changes and clinical features of AD as well as research progress on rTMS in the treatment of AD,aiming to provide new ideas for studying the pathogenesis and treatment of AD.

关 键 词：阿尔茨海默病 重复经颅磁刺激 认知障碍 Aβ淀粉样蛋白 突触可塑性 神经炎症 

分 类 号：R749.16[医药卫生—神经病学与精神病学]