非小细胞肺癌患者PBMC中SITR1、Nrf2表达的临床意义及与预后的相关性  

Clinical Significance of SITR1 and Nrf2 in PBMC and Their Correlation with Prognosis of Patients with Non-small Cell Lung Cancer

作　　者：何震宇 宋星仪 师泽元 安小康[1] HE Zhenyu;SONG Xingyi;SHI Zeyuan(The First Affiliated Hospital of Henan University,Kaifeng,475000)

机构地区：[1]河南大学第一附属医院,475000

出　　处：《实用癌症杂志》2023年第8期1256-1259,共4页The Practical Journal of Cancer

基　　金：河南省2021年科技发展计划项目(编号:212102310700)。

摘　　要：目的 探究非小细胞肺癌(NSCLC)患者外周血单个核细胞(PBMC)中沉默信息调节因子1(SITR1)、核转录因子E2相关因子2(Nrf2)表达的临床意义及与预后的相关性。方法 选取84例NSCLC患者及同期健康体检的84例受试者为研究对象,检测2组受试者PBMC中SITR1、Nrf2表达,分析其表达与NSCLC患者临床病理特征的关系。随访3年,采用Kaplan-Meier法分析SITR1、Nrf2表达与预后的关系。结果 NSCLC患者PBMC中SITR1、Nrf2蛋白阳性表达量高于健康体检组(P<0.05)。NSCLC患者PBMC中SITR1、Nrf2阳性表达量与淋巴结转移、肿瘤直径、TNM分期情况有关(P<0.05)。随访至截止至2021年12月,总生存率为39.29%(33/84),以SITR1、Nrf2蛋白中位阳性表达量为界将NSCLC患者分为高表达组和低表达组,SITR1高表达组3年累计生存率(16.67%)显著低于SITR1低表达组(61.90%),差异有统计学意义(χ^(2)=18.018,P<0.001);Nrf2高表达组3年累计生存率(23.81%)显著低于Nrf2低表达组(54.76%),差异有统计学意义(χ^(2)=8.435,P=0.004)。结论 SITR1、Nrf2表达在NSCLC患者PBMC中明显升高,其与淋巴结转移、肿瘤直径、TNM分期显著相关,且高表达SITR1、Nrf2患者的3年生存率显著降低。Objective To explore the clinical significance of silent information regulator 1(SITR1) and nuclear factor E2-related factor 2(Nrf2) in peripheral blood mononuclear cells(PBMC) and their correlation with prognosis of patients with non-small cell lung cancer(NSCLC).Methods A total of 84 patients with NSCLC and 84 healthy controls were enrolled as the research objects.The expressions of SITR1 and Nrf2 in PBMCs in both groups were detected.And their relationship with clinicopathological characteristics of NSCLC patients was analyzed.After 3 years of follow-up,the relationship between SITR1,Nrf2 and prognosis was analyzed by Kaplan-Meier.Results The positive expression of SITR1 and Nrf2 proteins in PBMCs in NSCLC patients were higher than those in the healthy physical examination group(P<0.05).The positive expression of SITR1 and Nrf2 proteins were related to lymph node metastasis,tumor diameter and TNM staging(P<0.05).The overall survival rate was 39.29%(33/84).According to positive expression of SITR1 and Nrf2 proteins,NSCLC patients were divided into high-expression group and low-expression group.The 3-year cumulative survival rate in SITR1 high-expression group was significantly lower than that in SITR1 low-expression group(16.67% vs 61.90%)(χ^(2)=18.018,P<0.001).The 3-year cumulative survival rate in Nrf2 high-expression group was significantly lower than that in Nrf2 low-expression group(23.81% vs 54.76%)(χ^(2)=8.435,P=0.004).Conclusion The expression of SITR1 and Nrf2 in PBMC significantly increased in NSCLC patients,which are significantly correlated with lymph node metastasis,tumor diameter and TNM staging.The 3-year survival rate is significantly decreased in patients with high expressions of SITR1 and Nrf2.

关 键 词：非小细胞肺癌 外周血单个核细胞 沉默信息调节因子1 核转录因子E2相关因子2 预后 

分 类 号：R734.2[医药卫生—肿瘤]