软组织修复医用材料及产品的研究进展  

Research Advances in Medical Materials and Products for Soft Tissue Repairs

作　　者：李佳琪 王蕊 韩倩倩[1] 孙雪[1] LI Jiaqi;WANG Rui;HAN Qianqian;SUN Xue(National Institutes for Food and Drug Control,Beijing,102629;China Pharmaceutical University,Nanjing,210000)

机构地区：[1]中国食品药品检定研究院,北京市102629 [2]中国药科大学,南京市210000

出　　处：《中国医疗器械杂志》2023年第4期415-423,共9页Chinese Journal of Medical Instrumentation

基　　金：中国科学院“器官重建与制造”战略性先导专项(XDA16040602);国家重点研发计划项目(2022YFC2401802)。

摘　　要：软组织是人体内一类不可或缺的组织,它有着保护机体免遭外界物理化学因素或生物因素侵害的重要作用。轻度软组织损伤能够自愈,但重度软组织损伤可能需要进行相关治疗。天然高分子材料(如壳聚糖、透明质酸、胶原蛋白)与合成高分子材料(如聚乙二醇、聚乳酸)具有良好的生物相容性、生物降解性与低毒性,用于软组织修复,可起到抗菌、止血与促进创面愈合的作用,通过改性或制备复合材料的方法可提升相关性能。常用的软组织修复产品有伤口敷料、生物补片、医用组织黏合剂、组织工程支架等。该研究主要对包括壳聚糖、透明质酸、胶原蛋白、聚乙二醇和聚乳酸在内的各类软组织修复医用材料的性质、作用机制及产品的应用进行介绍,并对软组织修复医用材料及产品的应用前景进行展望。Soft tissue is an indispensable tissue in human body.It plays an important role in protecting the body from external physical,chemical or biological factors.Mild soft tissue injuries can self-heal,while severe soft tissue injuries may require related treatment.Natural polymers(such as chitosan,hyaluronic acid,and collagen)and synthetic polymers(such as polyethylene glycol and polylactic acid)exhibit good biocompatibility,biodegradability and low toxicity.It can be used for soft tissue repairs for antibacterial,hemostatic and wound healing purposes.Their related properties can be enhanced through modification or preparation of composite materials.Commonly used soft tissue repairs include wound dressings,biological patches,medical tissue adhesives,and tissue engineering scaffolds.This study introduces the properties,mechanisms of action and applications of various soft tissue repair medical materials,including chitosan,hyaluronic acid,collagen,polyethylene glycol and polylactic acid,and provides an outlook on the application prospects of soft tissue repair medical materials and products.

关 键 词：软组织 材料 产品 

分 类 号：R318.08[医药卫生—生物医学工程] TH77[医药卫生—基础医学] R197.39[机械工程—仪器科学与技术]