Nampt在三阴性乳腺癌中的表达及与Ki67的关系  

Relationship between the expression of nicotinamide phosphoribosyl transferase(Nampt)and Ki67 in the triple negative breast cancer(TNBC)

作　　者：孙亚君 邹芳芳 邹腾跃 尹俊倩 毕铁强 SUN Ya-jun;ZOU Fang-fang;ZOU Teng-yue;YIN Jun-qian;BI Tie-qiang(Weifang Medical University Weifang 264300,China;Department of Pathology,Weihai Municipal Hospital,Affiliated to Shandong University Weihai264200,China;Department of Thyroid and Breast Surgery,Weihai Municipal Hospital,Affiliated to Shandong University Weihai264200,China)

机构地区：[1]潍坊医学院,山东潍坊264300 [2]山东大学附属威海市立医院病理科,山东威海264200 [3]山东大学附属威海市立医院乳腺甲状腺外二科,山东威海264200

出　　处：《中国现代普通外科进展》2023年第7期548-552,共5页Chinese Journal of Current Advances in General Surgery

摘　　要：目的:探讨三阴性乳腺癌(TNBC)中烟酰胺磷酸核糖基转移酶(Nampt)的表达及与Ki67的关系,为TNBC的治疗找到新的靶点及预测指标。方法:选取2013年1月—2017年12月山东大学附属威海市立医院甲状腺乳腺外科400例乳腺癌患者的临床资料,未行化疗且病历资料完整,根据其免疫组织化学及荧光原位杂交检测结果将其分为TNBC和非TNBC。调取其手术后组织蜡块制作组织芯片,运用免疫组织化学技术测定不同类型乳腺癌组织中Nampt及Ki-67的表达情况。利用SPSS23.0对结果进行分析,利用χ^(2)检验对TNBC及其他类型乳腺癌中Nampt的表达率进行组间比较。采用二元Logistic回归对TNBC中Nampt的表达与临床病理学特征之间的关系进行分析。运用线性回归方法检验Nampt与Ki67表达之间的关系;采用Kaplan-Meier法绘制生存曲线。结果:TNBC组织中Nampt的表达率高于其他类型的乳腺癌(54.3%比14.7%,P<0.05);在TNBC中Nampt的表达程度与淋巴结转移情况相关(P=0.026),与肿瘤大小及年龄无关(P>0.05);在TNBC中,Nampt的表达越高,Ki67的表达越高(r=0.671,P<0.001),Nampt高表达患者的3年无病生存期低于Nampt低表达患者(P=0.023)。结论:Nampt在TNBC中的表达率更高,这可能与TNBC的高侵袭性相关,高表达的Nampt可能预示着不良预后,Nampt有望联合Ki67成为指导TNBC预后及治疗的新靶点。Objective:To explore the expression of nicotinamide phosphoribosyl transferase(Nampt)in TNBC and the correlation with Ki67 in the TNBC,and to find new targets and predictive indicators for the treatment of TNBC.Methods:We collected 400 cases of TNBC patients which have complete pathological data from January 2013 to December 2017 in the Department of Thyroid and Breast Surgery,Weihai Municipal Hospital,Cheeloo College of Medicine,Shandong University.The patients were divided into two groups(TNBC,non-TNBC),according to the results of immunohistochemistry.Both groups were further classified according to the clinico-pathological ariables.SPSS 23.0 was used for statistical analysis,chi square test for comparison between groups,binary logistic regression analysis for the relation between Nampt and clinicopathological features,linear regression analysis for the relation between Nampt and Ki67,was statisticalsignificance,the prognostic value of visfatin was evaluated by Kaplan-Meier estimates(P<0.05).Results:The expression of Nampt in TNBC was significantly higher than that in non-TNBC(54.3%vs.14.7%P<0.05);the expression of Nampt were correlated with lymph node metastasis(P=0.026)and not correlated with tumor size(P>0.05);there was positive correlation between Nampt and Ki67.Higher Nampt expression was associated with poor disease free survival in TNBC.Conclusion:In TNBC,the expression of Nampt in the TNBC is higher than it in the non-TNBC.Higher expression of Nampt maybe indecate poorer prognosis.A new therapeutic strategy may be found to conquer TNBC.

关 键 词：三阴性乳腺癌 烟酰胺磷酸核糖基转移酶 KI67 组织芯片 

分 类 号：R737.9[医药卫生—肿瘤]