伴失眠症状的忧郁型抑郁患者睡眠质量评分与抑郁严重程度、认知功能相关性  

Correlations between sleep quality score,depression severity and cognitive function in melancholic depression patients with insomnia

作　　者：蒙培培 张云巧 崔雅莲 王彦芳[1] MENG Peipei;ZHANG Yunqiao;CUI Yalian;WANG Yanfang(Department of Psychiatry,The First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一医院精神卫生科,太原030001

出　　处：《山东医药》2023年第21期11-14,共4页Shandong Medical Journal

基　　金：国家重点研发计划(2016YFC1307103);山西省卫健委科研基金项目(2022140);山西省136兴医工程项目。

摘　　要：目的观察伴失眠症状的忧郁型抑郁患者睡眠质量评分与抑郁严重程度、认知功能的相关性。方法忧郁型抑郁患者70例,采用匹兹堡睡眠质量指数(PSQI)量表测算,两组患者睡眠质量评分,依据PSQI评分分为失眠组(PSQI评分>7分)50例、无失眠组(PSQI评分≤7分)20例。采用17项汉密尔顿抑郁量表(Hamilton depression scale,HAMD17)评估两组患者的抑郁严重程度;采用64导ESI-128型事件相关电位(ERP)系统与E-prime 2.0软件检测两组患者的ERP各成分潜伏期,评估患者认知功能;采用偏相关分析法分析失眠组患者睡眠质量评分与抑郁严重程度、认知功能的相关性。结果失眠组PSQI评分12(10,15)分,无失眠组PSQI评分7(5,7)分,两组相比,P<0.05。失眠组HAMD17总分、焦虑/躯体化因子评分、体重因子评分、睡眠障碍因子评分均高于无失眠组(P均<0.05)。失眠组患者的中线顶区(Pz)电极点N1潜伏期和中线前额(Fz)电极点N2潜伏期均高于无失眠组(P均<0.05)。失眠组患者的PSQI评分与HAMD17总分、焦虑/躯体化因子评分、睡眠障碍因子评分、Pz电极点N1潜伏期呈正相关(r分别为0.321、0.379、0.408、0.242,P均<0.05)。结论伴失眠症状的忧郁型抑郁患者睡眠质量评分越低,患者的抑郁程度和认知功能障碍越严重。Objective To observe the correlations between sleep quality score and depression severity and cognitive function in melancholic depression patients with insomnia.Methods Seventy patients with melancholic depression,measured by the Pittsburgh Sleep Quality Index(PSQI)scale,were divided into the insomnia group(PSQI score>7)of 50 cases and the non-insomnia group(PSQI score≤7)of 20 cases based on the PSQI score.The 17-item Hamilton Depression Rating Scale(HAMD17)was used to assess the severity of depression in the two groups.The 64-lead ESI-128 event-related potential(ERP)system with E-prime 2.0 software was used to detect the latency of each component of ERP and we assessed the cognitive function of patients in both groups.The correlations between the sleep quality score and the severity of depression and cognitive function of patients in the insomnia group were analyzed by partial correlation analysis.Results The PSQI score was 12(10,15)in the insomnia group and 7(5,7)in the non-insomnia group,with statistically significant difference between the two groups(P<0.05).The total HAMD17 score,anxiety/somatization factor score,weight factor score,and sleep disturbance factor score were higher in the insomnia group than in the non-insomnia group(all P<0.05).Patients in the insomnia group had higher midline parietal zone(Pz)electrode site N1 latency and midline prefrontal(Fz)electrode site N2 latency than those in the non-insomnia group(all P<0.05).The PSQI scores of patients in the insomnia group were positively correlated with the total HAMD17 score,anxiety/somatization factor score,sleep disturbance factor score,and Pz electrode point N1 latency(r=0.321,0.379,0.408,and 0.242,respectively;all P<0.05).Conclusion The lower the sleep quality scores of melancholic depression patients with insomnia symptoms,the more severe the patients'depression level and cognitive dysfunction.

关 键 词：抑郁 忧郁型抑郁 失眠 睡眠质量 认知功能 匹兹堡睡眠质量指数 17项汉密尔顿抑郁量表 事件相关电位 

分 类 号：R749.4[医药卫生—神经病学与精神病学]