湖北十堰地区某公司7421例员工普通体检代谢相关脂肪性肝病检出结果分析  

Analysis on detection results of MAFLD in 7421 employees of a company in Shiyan,Hubei Province during regular physical examination

作　　者：吴车敏 张从玉 徐慧丽 黄慧敏[2] 李秀楼[3] 姜雪强[1] WU Chemin;ZHANG Congyu;XU Huili;HUANG Huimin;LI Xiulou;JIANG Xueqiang(Department of Infectious Diseases Division,Guoyao Dongfeng General Hospital,Hubei University of Medicine,Shiyan 442000,China;不详)

机构地区：[1]湖北医药学院附属国药东风总医院感染性疾病科,湖北十堰442000 [2]湖北医药学院附属国药东风总医院医学实验中心 [3]湖北医药学院附属国药东风总医院健康管理中心

出　　处：《山东医药》2023年第21期35-39,共5页Shandong Medical Journal

基　　金：2022年十堰市引导性科研项目(22Y91);湖北省十堰市“创新创业战略团队”(十科联{2021}9号-13);2021年卓越计划(院内立项)青年人才项目(2021Q20)。

摘　　要：目的了解湖北十堰地区某公司7421例员工普通体检代谢相关脂肪性肝病(MAFLD)的患病情况,以及MAFLD患病的影响因素。方法进行健康体检的东风公司员工7421例,依据MAFLD诊断标准分为MAFLD组2839例、非MAFLD组4582例。收集入选体检者的性别、年龄等资料,计算不同性别及年龄MAFLD患病率。收集两组体检者的一般资料和血液生化指标信息,包括年龄、BMI、丙氨酸转氨酶(ALT)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血小板计数(PLT)、空腹血糖、尿酸等。以是否患有MAFLD为因变量,以单因素分析中差异有统计学意义的指标为自变量并赋值,多因素Logistic回归分析7421例体检者MAFLD患病的影响因素。结果7421例体检者中MAFLD患病率为38.3%,其中男性患病率为43.8%、女性患病率为17.1%,男性患病率显著高于女性(P<0.05),男性MAFLD患者年龄<30岁、30~39岁、40~49岁、≥50岁者患病率均高于女性(P均<0.05)。3309例非MAFLD组男性体检者的年龄、ALT、TG、TC、HDL-C、LDL-C、PLT、超重/肥胖检出率、空腹血糖异常检出率、高尿酸血症检出率等指标与2576例MAFLD组男性体检者相比,P均<0.05。1273例非MAFLD组女性体检者的年龄、ALT、TG、TC、HDL-C、LDL-C、PLT、超重/肥胖检出率、空腹血糖异常检出率、高尿酸血症检出率等指标与263例MAFLD组女性体检者相比,P均<0.05。Logistic回归分析结果显示,年龄、ALT、TG、HDL-C、PLT、超重/肥胖、空腹血糖异常、高尿酸血症是5885例男性体检者MAFLD患病的影响因素,ALT、TG、HDL-C、超重/肥胖、高尿酸血症是1536例女性体检者MAFLD患病的影响因素。结论湖北十堰地区某公司7421例员工中MAFLD患病率偏高,男性患病率高于女性,年龄、ALT、TG、HDL-C、PLT、超重/肥胖、空腹血糖异常、高尿酸血症是男性体检者MAFLD患病的影响因素,ALT、TG、HDL-C、超重/肥�Objective To investigate the prevalence of metabolic associated fatty liver disease(MAFLD)in 7421 employees of a company in Shiyan,Hubei Province,and the influencing factors of MAFLD.Methods According to the diagnostic criteria of MAFLD,7421 employees of Dongfeng Company who underwent physical examination were divided into the MAFLD group of 2839 cases and non-MAFLD group of 4582 cases.The gender,age and other data were collected,and we calculated the prevalence rate of MAFLD of different genders and ages.General data and blood biochemical indicators of the two groups were collected,including age,BMI,alanine aminotransferase(ALT),triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),platelet count(PLT),fasting blood glucose,uric acid,etc.With the presence or absence of MAFLD as the dependent variable and the indicators with statistical significance in the univariate analysis as independent variables and assigned values,multivariate Logistic regression analysis was conducted to analyze the influencing factors of MAFLD in 7421 cases of physical examination.Results The prevalence of MAFLD among 7421 subjects was 38.3%,with 43.8%in males and 17.1%in females.The prevalence of MAFLD in males was significantly higher than that in females(P<0.05).The prevalence of male MAFLD patients<30 years old,30-39 years old,40-49 years old,and≥50 years old was higher than that of female patients(P<0.05).Significant differences were found in the age,ALT,TG,TC,HDL-C,LDL-C,PLT,the detection rate of overweight/obesity,the detection rate of impaired fasting glucose,and the detection rate of hyperuricemia between 3309 male physical examination subjects of the non-MAFLD group and 2576 male subjects in the MAFLD group(all P<0.05).Significant differences were found in the age,ALT,TG,TC,HDL-C,LDL-C,and PLT,the detection rate of overweight/obesity,the detection rate of impaired fasting glucose,and the detection rate of hyperuricemia between 1273 non-MAFLD female subjects

关 键 词：脂肪性肝病 代谢相关脂肪性肝病 患病率 健康体检 

分 类 号：R575.5[医药卫生—消化系统]