液体活检在胸部恶性肿瘤诊疗应用的前景与挑战  

The prospect and challenge of liquid biopsy in the diagnosis and treatment of chest malignancy

作　　者：马丽芳 曾冰洁 王先照 张骁 王佳谊 Ma Lifang;Zeng Bingjie;Wang Xianzhao;Zhang Xiao;Wang Jiayi(Department of Clinical Laboratory,Shanghai Chest Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China;Institute of Thoracic Oncology,Shanghai Chest Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China)

机构地区：[1]上海市胸科医院/上海交通大学医学院附属胸科医院检验科,上海200030 [2]上海市胸科医院/上海交通大学医学院附属胸科医院胸部肿瘤研究所,上海200030

出　　处：《中华预防医学杂志》2023年第7期968-975,共8页Chinese Journal of Preventive Medicine

基　　金：国家自然科学基金项目(82173015,82273139,81871907,81902315);上海市科委“科技创新行动计划”实验动物研究领域项目(21140902800);上海市科委启明星计划(22QA1408300);上海市胸科医院院内卓越人才培育计划(2021YNZYJ01,2021YNZYY02)。

摘　　要：近年来,我国胸部恶性肿瘤的发病率逐年上升,已经严重威胁到群众的健康问题。其中,对胸部恶性肿瘤患者进行早期筛查并干预是癌症预防的关键。早发现、早诊断、早治疗作为临床的“三早预防”有利于提高恶性肿瘤患者的生存率。液体活检兼具非侵入性和实时反映肿瘤状态的特点,在临床诊疗中逐渐受到重视。循环肿瘤DNA(ctDNA)、循环肿瘤细胞(CTCs)和外泌体(exosomes)作为液体活检(liquid biopsy)的“三驾马车”,不仅在胸部恶性肿瘤诊断、监测和预后评估方面具有广泛的应用前景,同时也面临着许多挑战。本文就近年来液体活检在胸部恶性肿瘤中的应用进行详细阐述,为临床上胸部恶性肿瘤预防和诊疗策略的制定提供参考。In recent years,the incidence of chest malignant tumors in China has increased year by year,which has seriously threatened the health problems of people.Among them,early screening and intervention of patients with chest malignancies is the key to cancer prevention.Early detection,early diagnosis,and early treatment as the"three early prevention"of clinical practice are conducive to improve the survival rate of tumor patients.As a non-invasive and real-time reflection of tumor status,liquid biopsy has gradually received attention in clinical diagnosis and treatment.Circulating tumor cells(CTCs),circulating tumor DNA(ctDNA)and exosomes as liquid biopsy"Three carriages"are not only widely used in the diagnosis,monitoring and prognostic evaluation of chest malignancies,but also face many unknown challenges.In this article,the application of liquid biopsy in chest malignancies in recent years is elaborated in detail,which provides a reference for the formulation of clinical tumor prevention and diagnosis and treatment strategies.

关 键 词：液体活检 循环肿瘤DNA 循环肿瘤细胞 肿瘤诊断 预后评估 

分 类 号：R734[医药卫生—肿瘤]