银杏叶提取物注射液辅助治疗老年缺血性脑血管病的效果及对患者血液流变学、凝血功能的影响  

Effect of Extract of Ginkgo Biloba Leaves Injection in Adjuvant Treatment of Senile Patients with Ischemic Cerebral Vascular Disease and Its Influence on Hemorheology and Coagulation Function

作　　者：吴建伟 林强 郑剑钧 龚绍赟 WU Jianwei;LIN Qiang;ZHENG Jianjun;GONG Shaoyun(Shangrao Municipal Hospital,Jiangxi Province,Shangrao 334000,China;不详)

机构地区：[1]江西省上饶市立医院,江西上饶334000

出　　处：《中国医学创新》2023年第20期11-15,共5页Medical Innovation of China

摘　　要：目的:探讨银杏叶提取物注射液辅助治疗老年缺血性脑血管病的效果及对患者凝血功能、血液流变学的影响。方法:将2021年1月—2022年12月上饶市立医院接收的老年缺血性脑血管病患者共120例作为研究主体,以随机数字表法分为观察组和对照组,各60例。对照组给予基础治疗,观察组在对照组的基础上辅以银杏叶提取物注射液治疗,两组均连续治疗7 d。比较两组治疗前后血液流变学[全血(高切、低切)黏度、血浆黏度、红细胞压积、血小板聚集率及网织红细胞]、凝血功能[纤维蛋白原(FIB)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、凝血酶原时间(PT)、血小板第4因子(PF4)]、美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数,并对不良反应和疗效进行评估。结果:治疗后,观察组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后观察组NIHSS评分低于对照组,Barthel指数高于对照组,差异均有统计学意义(P<0.05)。治疗后、观察组全血高切黏度、全血低切黏度、血浆黏度、网织红细胞及血小板聚集率均低于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组FIB、PF4均低于对照组,APTT长于对照组,差异均有统计学意义(P<0.05)。治疗后,两组红细胞压积、TT、PT比较,差异均无统计学意义(P>0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:银杏叶提取物注射液辅助治疗缺血性脑血管病可显著提高效果,降低血液黏度,改善血液流变学和凝血功能。Objective:To explore the effect of Extract of Ginkgo Biloba Leaves Injection in adjuvant treatment of senile patients with ischemic cerebral vascular disease and its influence on hemorheology and coagulation function.Method:A total of 120 senile patients with ischemic cerebral vascular disease admitted to Shangrao Municipal Hospital from January 2021 to December 2022 were divided into observation group and control group according to random number table method,with 60 cases in each group.The control group was treated with basic treatment,and the observation group was treated with Extract of Ginkgo Biloba Leaves Injection on the basis of the control group.Both groups were treated continuously for 7 days.The hemorheology[whole blood(high shear,low shear)viscosity,plasma viscosity,hematocrit,platelet aggregation rate and reticulocyte],coagulation function[fibrinogen(FIB),activated partial thromboplastin time(APTT),thrombin time(TT),prothrombin time(PT),platelet factor 4(PF4)],national institute of health stroke scale(NIHSS)scores and Barthel index before and after treatment were compared between the two groups,and adverse reactions and curative effects were evaluated.Result:After treatment,the total effective rate of observation group was higher than that of control group,the difference was statistically significant(P<0.05).After treatment,the NIHSS score of observation group was lower than that of control group,and the Barthel index of observation group was higher than that of control group,the differences were statistically significant(P<0.05).After treatment,whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity,reticulocyte and platelet aggregation rate in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,FIB and PF4 in the observation group were lower than those in the control group,and APTT in the observation group was longer than that in the control group,the differences were statistical significanc

关 键 词：银杏叶提取物注射液 缺血性脑血管病 血液流变学 凝血功能 

分 类 号：R743[医药卫生—神经病学与精神病学]