血必净注射液联合经皮肝穿刺胆道引流术对急性梗阻性化脓性胆管炎患者血常规及肝肾功能的影响  

Effects of Xuebijing Injection Combined with Percutaneous Transhepatic Biliary Drainage on Blood Routine and Liver and Renal Function in Patients with Acute Obstructive Suppurative Cholangitis

作　　者：曾繁林[1] 林洁[1] 尹玲[1] 谢斌辉[1] 何晓[1] ZENG Fanlin;LIN Jie;YIN Ling;XIE Binhui;HE Xiao(The First Affiliated Hospital of Gannan Medical University,Ganzhou 341000,China;不详)

机构地区：[1]赣南医学院第一附属医院,江西赣州341000

出　　处：《中国医学创新》2023年第21期18-23,共6页Medical Innovation of China

基　　金：江西省中医药科研课题项目(2020B0090)。

摘　　要：目的:分析急性梗阻性化脓性胆管炎患者采用血必净注射液联合经皮肝穿刺胆道引流术治疗的临床效果。方法:回顾性分析赣南医学院第一附属医院2021年4月—2022年12月收治的83例急性梗阻性化脓性胆管炎患者临床资料,均行急诊经皮肝穿刺胆道引流术,根据其不同围手术期治疗方案分组,将常规对症治疗患者纳入参照组(41例),将常规对症治疗联合血必净静脉滴注治疗患者纳入研究组(42例)。比较两组治疗前后血常规(血小板计数、白细胞计数、血红蛋白)、肝功能指标(谷草转氨酶、谷丙转氨酶、总胆红素、直接胆红素)、肾功能指标(血清肌酐、尿素氮)、凝血功能指标(凝血酶原时间、活化部分凝血活酶时间、凝血酶时间、纤维蛋白原)水平,并记录和对比两组术后症状减轻时间、住院时间,统计两组病情缓解率。结果:治疗后,研究组白细胞计数水平低于参照组,血小板计数、血红蛋白水平均高于参照组,差异均有统计学意义(P<0.05);治疗后,研究组谷草转氨酶、谷丙转氨酶、总胆红素、直接胆红素、血清肌酐、尿素氮水平均低于参照组,差异均有统计学意义(P<0.05);治疗后,研究组凝血酶原时间、活化部分凝血活酶时间、凝血酶时间均短于参照组,纤维蛋白原水平高于参照组,差异均有统计学意义(P<0.05)。研究组症状缓解时间、住院时间均短于参照组,差异均有统计学意义(P<0.05)。研究组病情缓解率为95.24%,高于参照组的80.49%,差异有统计学意义(χ^(2)=4.260,P=0.039)。结论:采用血必净注射液联合经皮肝穿刺胆道引流术治疗急性梗阻性化脓性胆管炎可显著改善患者血常规,恢复凝血功能,减轻肝肾功能受损,加快术后恢复进程,临床疗效显著,预后理想。Objective:To analyze the clinical effect of Xuebijing Injection combined with percutaneous transhepatic biliary drainage in the treatment of acute obstructive suppurative cholangitis.Method:A retrospective analysis was made of the clinical data of 83 patients with acute obstructive suppurative cholangitis admitted to the First Affiliated Hospital of Gannan Medical University from April 2021 to December 2022.All patients underwent emergency percutaneous transhepatic puncture and biliary drainage,and were grouped according to their different perioperative treatment plans.Patients with routine symptomatic treatment were included in the reference group(41 cases),and patients with routine symptomatic treatment combined with intravenous drip of Xuebijing were included in the study group(42 cases).The levels of blood routine tests(platelet count,white blood cell count,hemoglobin),liver function indicators(glutamic oxaloacetic transaminase,glutamic-pyruvic transaminase,total bilirubin,direct bilirubin),renal function indicators(serum creatinine,urea nitrogen)and coagulation function indicators(prothrombin time,activated partial thromboplastin time,thrombin time and fibrinogen)before and after treatment between the two groups were compared,the time of symptom relief and hospital stay between the two groups were recorded and compared,and the remission rate of the two groups was calculated.Result:After treatment,the white blood cell count of the study group was lower than that of the reference group,and the platelet count and hemoglobin level were higher than those of the reference group,the differences were statistically significant(P<0.05);after treatment,glutamic-oxaloacetic transaminase,glutamic-pyruvic transaminase,total bilirubin,direct bilirubin,serum creatinine and blood urea nitrogen levels the in the study group were lower than those in the reference group(P<0.05).After treatment,the prothrombin time,activated partial thromboplastin time,and thrombin time in the study group were shorter than those in the reference

关 键 词：血必净 急性梗阻性化脓性胆管炎 血小板计数 谷草转氨酶 

分 类 号：R575.7[医药卫生—消化系统]