肉豆蔻化学成分和药理作用研究进展及其质量标志物(Q-Marker)预测分析  

Research progress on chemical composition and pharmacological effects of Myristicae Semen and predictive analysis on its quality marker

作　　者：刘润润 孙爱清 于小钧 贺梦媛 谢和兵 高鹏[4] 丛竹凤 LIU Run-run;SUN Ai-qing;YU Xiao-jun;HE Meng-yuan;XIE He-bing;GAO Peng;CONG Zhu-feng(College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;The Affiliated Cancer Hospital,Shandong First Medical University,Jinan 250117,China;Tibet God Monkey Pharmaceutical Co.,Ltd.,Shigatse 330006,China;Institute of Pharmaceutical Research,Shandong University of Traditional Chinese Medicine,Jinan 250355,China)

机构地区：[1]山东中医药大学药学院,山东济南250355 [2]山东第一医科大学附属肿瘤医院 [3]西藏神猴药业有限责任公司,西藏日喀则330006 [4]山东中医药大学药物研究院,山东济南250355

出　　处：《中草药》2023年第14期4682-4700,共19页Chinese Traditional and Herbal Drugs

基　　金：中央引导地方科技发展专项:二十味肉豆蔻丸品质提升及二次开发研究(YDZX2021083-04)。

摘　　要：肉豆蔻Myristicae Semen是常用药食同源中药,具有温中行气、涩肠止泻的功效,主要包括木脂素类、挥发油类和多酚类等化学成分,具有调节消化系统、抗癌、抗炎镇痛、抗菌、抗氧化等药理作用。通过对肉豆蔻化学成分、药理作用、毒性和临床应用进行综述,根据中药质量标志物(quality marker,Q-Marker)理念,从植物亲缘、采收时期和炮制方法、药效、药性、配伍、化学成分可测性等方面对肉豆蔻的Q-Marker进行预测分析,初步预测去氢二异丁香酚、肉豆蔻醚、安五脂素、甲氧基丁香酚、榄香素、丁香酚和α-蒎烯等为其可能的Q-Marker,为肉豆蔻质量评价和药品研发提供参考。Roudoukou(Myristicae Semen) is a commonly used medicine and food homologous traditional Chinese medicine,which has the effects of warming the middle and moving qi,astringing the intestines and checking diarrhea.Its chemical components mainly include lignans,volatile oils and polyphenols.Myristicae Semen has the pharmacological effects of regulating the digestive system,anti-cancer,anti-inflammatory and analgesic,antibacterial and antioxidant,etc.This paper reviews its chemical constituents,pharmacological effects,toxicity studies and clinical applications.According to the concept of quality marker(Q-Marker) of traditional Chinese medicine,Q-Markers of Myristicae Semen was predicted from plant affinity,collecting periods and processing methods,efficacy,medicinal properties,compatibility,and chemical component measurability.It was preliminarily predicted that dehydrodiisoeugenol,myristicin,macelignan,methoxyeugenol,elementin,eugenol and α-pinene were the possible Q-Marker,to provid a reference for the quality evaluation and drug development of Myristicae Semen.

关 键 词：肉豆蔻 质量标志物 去氢二异丁香酚 肉豆蔻醚 安五脂素 甲氧基丁香酚 榄香素 丁香酚 Α-蒎烯 

分 类 号：R285[医药卫生—中药学]