中药多酚类成分抗肿瘤表观遗传机制的研究进展  

Research progress on antitumor epigenetic mechanism of polyphenols from traditional Chinese medicine

作　　者：王琴 杨斌 顾健 龚普阳 WANG Qin;YANG Bin;GU Jian;GONG Pu-yang(College of Pharmacy,Southwest Minzu University,Chengdu 610041,China)

机构地区：[1]西南民族大学药学院,四川成都610041

出　　处：《中草药》2023年第14期4722-4731,共10页Chinese Traditional and Herbal Drugs

基　　金：四川省自然科学基金资助项目(2022NSFSC1735);中央高校基本科研业务费专项基金项目青年成长项目(ZYN2022094)。

摘　　要：表观遗传调控紊乱导致的基因表达异常是肿瘤的发生的重要特征之一。近年来,中药活性成分调控肿瘤表观遗传机制研究成为热点。多酚是多种抗肿瘤中药的主要物质基础。姜黄素、表没食子儿茶素没食子酸酯、白藜芦醇、槲皮素和原花青素等可通过多种表观遗传机制调控肿瘤抑制基因或癌基因的表达,发挥抗肿瘤作用。通过对代表性中药多酚类成分调节DNA甲基化、组蛋白修饰和非编码RNA等表观遗传方面发挥抗肿瘤的作用进行综述,为中药对肿瘤的干预治疗提供理论依据和研究策略。Abnormal gene expression caused by epigenetic regulation is one of the important characteristics of tumor occurrence.In recent years,the research on the epigenetic mechanism of the active components of traditional Chinese medicine has become a hot topic.Polyphenols are the main basal components of many antitumor Chinese medicine.Curcumin,epigallocatechin gallate,resveratrol,quercetin and proanthocyanidins can regulate the expression of tumor suppressor genes or oncogenes through various epigenetic mechanisms,thus play an antitumor role.This paper discusses the antitumor effects of representative Chinese medicine polyphenols on epigenetic regulation of DNA methylation,histone modification,and non-coding RNA,to provide theoretical basis and research strategy for the treatment of traditional Chinese medicine on tumor.

关 键 词：表观遗传 多酚 肿瘤 DNA甲基化 组蛋白修饰 姜黄素 表没食子儿茶素没食子酸酯 白藜芦醇 槲皮素 原花青素 

分 类 号：R285[医药卫生—中药学]