青花椒精油柔性脂质体的制备及质量评价  

Preparation of Flexible Nanoliposomes of Volatile Oil from Zanthoxylum schinifolium and Its Quality Evaluation

作　　者：刘艳苓 董红霞 龙泽丽 韩阳 韩静 LIU Yanling;DONG Hongxia;LONG Zeli;HAN Yang;HAN Jing(School of Pharmaceutical Engineering,Shenyang Pharmaceutical University,Shenyang 110016;Faculty of Functional Food and Wine,Shenyang Pharmaceutical University,Shenyang 110016;Traditional Chinese Medicine College,Shenyang Pharmaceutical University,Shenyang 110016)

机构地区：[1]沈阳药科大学制药工程学院,沈阳110016 [2]沈阳药科大学功能食品与葡萄酒学院,沈阳110016 [3]沈阳药科大学中药学院,沈阳110016

出　　处：《食品工业》2023年第7期71-76,共6页The Food Industry

基　　金：沈阳药科大学大学生创新创业训练计划项目(202210163002);辽宁省博士启动基金(2022-BS-154)。

摘　　要：制备青花椒精油柔性脂质体,并考察其在小鼠体外的透皮吸收特征。采用薄膜-超声法,以包封率和粒径为指标,泊洛沙姆188为表面活性剂制备青花椒精油柔性脂质体,并对制备成功的柔性脂质体进行质量评价。通过优选制得的青花椒精油柔性脂质体平均粒径为115.81±2.11 nm(n=3),包封率为92.13%±2.77%,PDI为0.236±0.110(n=3),Zeta电位为-50.21±2.35 mV(n=3),纳米粒积累渗透量为149.24μg/cm^(2),是原料的1.77倍。该青花椒精油柔性脂质体制备工艺方便科学、稳定可行,粒径小且分布均匀,能够增加青花椒精油的经皮渗透,是一种良好的经皮给药载体。Prepare flexible liposomes of volatile oil from Zanthoxylum schinifolium,and investigate its properties and transdermal absorption behavior characteristics of its mouse skin in vitro.Poloxam 188 was prepared as flexible liposome for the volatile oil.On the basis,the flexible liposomes of volatile oil from Zanthoxylum schinifolium were prepared by membraneultrasonic method with entrapment efficiency and size as index,and the quality was evaluated.The mean particle size,entrapment efficiency,PDI and Zeta potential of the flexible liposomes of volatile oil from Zanthoxylum schinifolium prepared by optimization were 115.81±2.11 nm(n=3),92.13%±2.77%,0.236±0.110(n=3)and-50.21±2.35 mV(n=3),respectively.The accumulation and permeability of liposomes reached 149.24μg/cm^(2),1.77 times of the raw material.The flexible liposomes had small particle size,even distribution and high entrapment efficiency.Its preparation process of flexible liposomes is convenient,scientific,stable and feasible,and can promote the transdermal penetration of volatile oil from Zanthoxylum schinifolium,thus being a good transdermal drug delivery carrier.

关 键 词：青花椒精油 脂质体 Box-Behnken设计-响应面法 透皮吸收 

分 类 号：TQ460.1[化学工程—制药化工]