大蒜辣素保护心血管的药理作用及其机制研究进展  

Advances in cardiovascular protection effects and mechanisms of allicin

作　　者：阳莹[1] 李敏[1] 包海燕 李新霞[1,2] 李建光 YANG Ying;LI Min;BAO Hai-yan;LI Xin-xia;LI Jian-guang(College of Pharmacy,Xinjiang Medical University,,Urumqi 830011,China;Key Laboratory of High Incidence Diseases in Xinjiang,Ministry of Education,Urumqi 830011,China;Xinjiang University of Science and Technology,Korla 841000,China)

机构地区：[1]新疆医科大学药学院,新疆乌鲁木齐830011 [2]新疆地区高发疾病研究教育部重点实验室,新疆乌鲁木齐830011 [3]新疆科技学院,新疆库尔勒841000

出　　处：《中国中药杂志》2023年第13期3409-3420,共12页China Journal of Chinese Materia Medica

基　　金：新疆维吾尔自治区杰出青年科学基金项目(2022D01E17);新疆天然药物活性组分与释药技术重点实验室项目(XJDX1713);新疆省部共建中亚高发病成因与防治国家重点实验室开放课题(SKL-HIDCA-2018-11)

摘　　要：心血管疾病是全球发病率和病死率最高的疾病,严重危害人类健康。大蒜辣素作为大蒜最主要活性成分之一,不仅具有心血管保护作用,而且对心血管疾病的危险因素也具有一定的防治作用。体内、外研究表明,大蒜辣素主要通过抗氧化应激,抑制细胞凋亡,抑制自噬及炎症反应,调节脂质代谢、肠道微生物群,诱导硫化氢(hydrogen sulfide,H_(2)S)生成,舒张血管等途径发挥心血管保护作用。值得注意的是,虽然大蒜辣素有着较好的心血管保护作用,但其不稳定性,使得大蒜辣素的基础研究及临床应用受到一定阻碍。该文就近10年大蒜辣素保护心血管的药理作用及相关机制的研究,以及提高大蒜辣素稳定性的方法进行综述,以期为大蒜辣素在心血管领域进一步的研究与开发提供参考。Cardiovascular diseases(CVD)with high morbidity and mortality pose severe threats to human life.Allicin,a main active ingredient of garlic,possesses multiple pharmaceutical activities.It not only exerts cardioprotective effects but also prevents the risk factors for CVD.Allicin exerts cardioprotective effects via a variety of mechanisms,including inhibiting oxidative stress,apoptosis,autophagy,and inflammatory responses,regulating lipid metabolism and gut microbiota,inducing hydrogen sulfide production,and dilating vessels.Despite the valuable cardioprotective effects,the instability of allicin has hindered the basic research and clinical application.This paper reviews the progress in the cardioprotective effects and mechanisms of allicin in the last decade and summarizes the methods to improve the stability of allicin.In addition,this review provides a reference for further research and development of allicin in cardiovascular protection.

关 键 词：大蒜辣素 心血管疾病 心脏保护 血管保护 

分 类 号：R285[医药卫生—中药学]