非小细胞肺癌组织中磷酸化4E结合蛋白1表达及其与根治术后复发的关系  

Expression of p-4EBP1 protein in non-small cell lung cancer and its relationship with recurrence after radical resection

作　　者：王黎 占根生 何思东 肖志超 周存荣[1] WANG Li;ZHAN Gen-sheng;HE Si-dong(Department of Thoracic Surgery,Nanjing Pukou District Central Hospital,Nanjing(211899),China)

机构地区：[1]南京市浦口区中心医院,南京211899

出　　处：《中国中西医结合外科杂志》2023年第4期469-473,共5页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

摘　　要：目的:探讨非小细胞肺癌(NSCLC)组织中磷酸化4E结合蛋白1(p-4EBP1)表达及其与根治术后复发的关系。方法:选取本院2020年1月—2021年1月收治的111例行根治术的NSCLC患者,收集患者手术切除的肺癌组织和癌旁组织,采用免疫组化法检测肺癌组织及癌旁组织中p-4EBP1蛋白表达,比较不同临床病理特征NSCLC患者肺癌组织p-4EBP1蛋白表达情况。随访统计NSCLC患者术后1年复发情况,对比复发组(20例)和未复发组(91例)肺癌组织p-4EBP1蛋白表达,并采用多因素Cox回归模型分析NSCLC根治术后复发的影响因素。结果:肺癌组织p-4EBP1蛋白阳性表达率高于癌旁组织(70.27%vs 16.22%,P<0.05);临床分期Ⅲa期、低分化、淋巴结转移患者肺癌组织p-4EBP1蛋白阳性表达率分别高于临床分期Ⅰ/Ⅱ期、中高分化、无淋巴结转移患者(P<0.05);术后1年,111例患者的复发率为18.02%(20/111),复发组肺癌组织p-4EBP1蛋白阳性表达率高于未复发组(90.00%vs 65.93%,P<0.05);复发组有吸烟史、临床分期Ⅲa期、低分化、淋巴结转移占比均高于未复发组(P<0.05);多因素回归模型分析结果显示,吸烟史、临床分期Ⅲa期、低分化、淋巴结转移、肺癌组织p-4EBP1蛋白阳性表达均是NSCLC患者根治术后复发的危险因素(P<0.05)。结论:NSCLC患者癌组织中p-4EBP1蛋白阳性表达率高于癌旁组织,且与临床病理特征和术后复发关系密切,可能是NSCLC患者根治术后复发的危险因素。Objective To investigate the expression of phosphorylated4E binding protein 1(p-4EBP1)in non-small cell lung cancer(NSCLC)and its relationship with recurrence after radical resection.Methods 111 patients with NSCLC who underwent radical resection in our hospital from January 2020 to January 2021 were selected as the research subjects.The surgically resected lung cancer tissues and paracancerous tissues were collected,and immunohistochemistry was used to detect the lung cancer tissues and paracancerous tissues.The expression of p-4EBP1 protein in tissue was compared,and the expression of p-4EBP1 protein in lung cancer tissue of patients with different clinicopathological characteristics of NSCLC was compared.The 1-year recurrence rate of NSCLC patients after surgery was followed up,and the expression of p-4EBP1 protein in lung cancer tissue was compared between the recurrence group and the non-recurrence group.Results The positive expression rate of p-4EBP1 protein in lung cancer tissues was higher than that in adjacent tissues(70.27%vs 16.22%,P<0.05).The positive rates of p-4EBP1 protein expression in lung cancer tissues of patients with clinical stage IIIa,poorly differentiated and lymph node metastasis were higher than those of patients with clinical stage I/II,moderately and well differentiated and without lymph node metastasis(P<0.05).The recurrence rate at 1 year after operation was 18.02%(20/111),and the positive expression rate of p-4EBP1 protein in the lung cancer tissue of the recurrence group was higher than that of the non-recurrence group(90.00%vs 65.93%,P<0.05).The proportions of the recurrence group with smoking history,clinical stage IIIa,poor differentiation and lymph node metastasis were higher than those of non-recurrence group(P<0.05).Multivariate regression model analysis showed that smoking history,clinical stage IIIa,poor differentiation,lymph node metastasis,and positive expression of p-4EBP1 protein in lung cancer tissues were all risk factors for recurrence of NSCLC patients after radical

关 键 词：非小细胞肺癌 磷酸化4E结合蛋白1 临床病理特征 外科手术 复发 

分 类 号：R734.2[医药卫生—肿瘤]