A new perspective in pyroptosis:lifting the veil on GSDMA activation  

作　　者：Pian Yu Xiang Chen Cong Peng 

机构地区：[1]Department of Dermatology,Xiangya Hospital,Central South University,Changsha 410008,China [2]National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Changsha 410008,China [3]Hunan Key Laboratory of Skin Cancer and Psoriasis,Xiangya Hospital,Changsha 410008,China [4]Hunan Engineering Research Center of Skin Health and Disease,Xiangya Hospital,Changsha 410008,China [5]Xiangya Clinical Research Center for Cancer Immunotherapy,Central South University,Changsha 410008,China

出　　处：《Frontiers of Medicine》2023年第3期581-583,共3页医学前沿（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.82073458);Scientific Research and Innovation Project of postgraduates in Hunan Province(No.150110028).

摘　　要：Pyroptosis is an inflammatory form of death mediated by gasdermin that recruits immune cells to the site of infection and promotes protective immunity.The gasdermin is a family of pore-forming proteins,including GSDMA(Gsdma1,Gsdma2,Gsdma3),GSDMB,GSDMC(Gsdmc1,Gsdmc2,Gsdmc3,Gsdmc4),GSDMD(Gsdmd),GSDME/DFNA5(Dfna5)and GSDMF/DFNB59/PJVK(Dfnb59)[1,2].Though activation of GSDMB/C/D/E has been gradually illustrated[3],the details of GSDMA activation,particular in epithelial cells such as skin and upper gastrointestinal tract,still remain so far largely elusive.

关 键 词：protective ACTIVATION LIFTING 

分 类 号：R36[医药卫生—病理学]