噻吗洛尔滴眼液治疗婴幼儿浅表型血管瘤的meta分析  

Meta-analysis of timolol eye drops in the treatment of superficial hemangioma in infants

作　　者：徐锦龙 叶家兴 陈武 马卫成 Xu Jinlong;Ye Jiaxing;Chen Wu;Ma Weicheng(Department of Pharmacy,Yinzhou Second Hospital,Ningbo 315100,China;Department of Pharmacy,Yinzhou People′s Hospital,Ningbo 315100,China)

机构地区：[1]宁波市鄞州区第二医院临床药学部,浙江宁波315100 [2]宁波市鄞州人民医院药剂科,浙江宁波315100

出　　处：《中国医院统计》2023年第3期232-235,共4页Chinese Journal of Hospital Statistics

基　　金：浙江省药学会科技计划项目(2018ZYY38)。

摘　　要：目的对噻吗洛尔滴眼液治疗浅表型婴幼儿血管瘤进行meta分析。方法检索噻吗洛尔滴眼液治疗浅表型婴幼儿血管瘤的随机对照研究(RCTs),筛选文献、提取数据并评价研究质量,使用RevMan 5.3和Stata 11.0软件进行评价。结果纳入7项研究,共706例患者。meta分析结果显示,噻吗洛尔滴眼液治疗婴幼儿浅表型血管瘤的有效率、显效率明显高于对照组(P<0.001),而ADR发生率差异无统计学意义(P=0.570);年龄≤6个月与>6个月的婴幼儿相比,控制率差异无统计学差异(P=0.380),但消退率明显较高(P=0.004)。结论噻吗洛尔滴眼液治疗浅表型婴幼儿血管瘤安全有效,且年龄≤6个月的婴幼儿效果更佳。Objective To study the meta-analysis of timolol eye drops in the treatment of superficial hemangioma in infants.Methods Randomized controlled trials(RCTs)of timolol eye drops in the treatment of superficial infantile hemangioma were retrieved.Literature was screened,data were extracted and research quality was evaluated with RevMan 5.3 software and Stata 11.0 software.Results Seven studies involving 706 patients were included.The results of meta-analysis showed that the effective rate and marked efficiency of timolol eye drops in the treatment of superficial hemangioma in infants were significantly higher than those in the control group(P<0.001),while the incidence of ADR was not significantly different(P=0.570).Compared with infants aged less than 6 months and over 6 months,the control rate was not significantly different(P=0.380),but the regression rate was significantly higher(P=0.004).Conclusion Timolol eye drops are safe and effective in the treatment of superficial infantile hemangioma,and the effect is better in infants aged less than 6 months.

关 键 词：噻吗洛尔 婴幼儿 浅表型血管瘤 META分析 

分 类 号：R732.2[医药卫生—肿瘤]