2008-2021年湖南省健康人群脑膜炎奈瑟菌携带率和药物敏感性监测  

Surveillance for carriage and antibiotic susceptibility of Neisseria meningitidis among a healthy population in Hunan province,2008-2021

作　　者：刘然 方明礼[1] 夏昕[1] 贺子翔 戴德芳[1] 覃迪[1] 湛志飞[1] Liu Ran;Fang Mingli;Xia Xin;He Zixiang;Dai Defang;Qin Di;Zhan Zhifei(Hunan Provincial Center for Disease Control and Prevention,Hunan Provincial Key Laboratory of Microbial Molecular Biology,Changsha 410000,Hunan,China)

机构地区：[1]湖南省疾病预防控制中心,微生物分子生物学湖南省重点实验室,湖南长沙410000

出　　处：《中国疫苗和免疫》2023年第3期326-331,共6页Chinese Journal of Vaccines and Immunization

基　　金：国家科技重大专项(2018ZX10713003-002-008)。

摘　　要：目的分析湖南省健康人群脑膜炎奈瑟菌(Neisseria meningitidis,Nm)携带率和药物敏感性。方法2008-2021年在湖南省3个区县按年龄分层选择健康人群,采集咽拭子标本,进行Nm分离培养和药物敏感性试验,分析Nm携带率和耐药率。结果2008-2021年湖南省健康人群Nm总携带率为2.23%(175/7841);其中0-2岁、3-4岁、5-6岁、7-14岁、15-19岁、≥20岁分别为0.00%、0.45%、0.28%、4.04%、7.02%、1.44%;A群、B群、C群、X群、Y群、W135群、不可分群Nm分别为0.00%(0株)、1.65%(129株)、0.09%(7株)、0.00%(0株)、0.03%(2株)、0.03%(2株)、0.45%(35株)。143株Nm菌株对青霉素、氨苄西林、头孢噻肟、左氧氟沙星、环丙沙星、米诺环素、复方新诺明的总耐药率分别为1.4%、0.0%、0.0%、29.4%、25.9%、0.0%、86.0%。结论湖南省健康人群Nm携带率以青少年较高,B群和不可分群为优势Nm血清群。建议优化脑膜炎球菌疫苗免疫程序,加强B群Nm疫苗研制和合理使用抗生素。Objective To explore carriage and antibiotic sensitivity of Neisseria meningitidis(Nm)in a healthy population of Hunan province.MethodsWe collected oropharyngeal swab samples from healthy subjects in three counties of Hunan from 2008 to 2021 using an age-stratified random sampling method.We isolated Nm strains and tested them for antibiotic susceptibility to determine Nm carriage rates and antibiotic resistance rates.ResultsThe overall Nm carriage rate was 2.23%(175/7841)between 2008 and 2021.Carriage rates for 0-2-,3-4-,5-6-,7-14-15-19-,and≥20-year-olds were 0.00%,0.45%,0.28%,4.04%,7.02%,and 1.44%,respectively.Carriage rates for A,B,C,X,Y,W135,and non-groupable serogroups of Nm were 0.00%,1.65%(129 strains),0.09%(7 strains),0.00%,0.03%(2 strains),0.03%(2 strains),and 0.45%(35 strains).Resistance of 143 Nm strains to penicillin,ampicillin,cefotaxime,levofloxacin,ciprofloxacin,minocycline,and trimethoprim-sulfamethoxazole were 1.4%,0.0%,0.0%,29.4%,25.9%,0.0%,and 86.0%.ConclusionsNm carriage was high among adolescents of Hunan.Serogroup B and non-groupable serogroups were predominant.We suggest optimizing immunization schedules for meningococcal vaccines,developing serogroup B meningococcal vaccine,and using antibiotics appropriately.

关 键 词：脑膜炎奈瑟菌 血清群 携带率 药物敏感性 

分 类 号：R183.3[医药卫生—流行病学]