老年食管癌累及野照射和淋巴结预防性照射的对比研究  

Comparison of Involution-field Irradiation and Elective Nodal Irradiation in Elderly Patients with Esophageal Cancer

作　　者：刘芳[1] 谭榜宪[1] 黄清梅 LIU Fang;TAN Bangxian;HUANG Qingmei(Department Oncology,Affiliated Hospital of North Sichuan Medical College,Nanchong,Sichuan Province,637000 China)

机构地区：[1]川北医学院附属医院肿瘤科,四川南充637000

出　　处：《世界复合医学》2023年第6期160-163,共4页World Journal of Complex Medicine

基　　金：四川省卫健委2016年度课题(16PJ129)。

摘　　要：目的对比根治性单纯放疗的老年食管癌患者行选择性淋巴结预防性照射(elective nodal irradiation,ENI)和累及野照射(involved-field irradiation,IFI)的疗效和不良反应,进一步探讨老年患者行累及野照射的可行性。方法回顾性分析2018年1月—2020年1月川北医学院附属医院放疗中心收治的62例老年食管癌患者的临床资料。按放疗靶区不同分为ENI组30例,IFI组32例,比较两组无进展生存率、总生存率、近期疗效、放射性肺炎、放射性食管炎情况。结果两组患者近期疗效比较,差异无统计学意义(P>0.05);随访两组患者1、2年总生存率及无进展生存率,经比较,差异无统计学意义(P>0.05);在不良反应发生率方面,IFI组的放射性肺炎发生率为25.00%、放射性食管炎发生率为18.75%,均明显低于ENI组,差异有统计学意义(χ^(2)=4.147、5.522,P<0.05)。结论老年食管癌患者行单纯放疗时,IFI和ENI的近期疗效、无进展生存率和总生存率相当,但IFI减少了老年患者放射性肺炎和放射性食管炎的发生率,是更适合老年食管癌的放疗方式。Objective To compare the efficacy and adverse reaction of elective nodal irradiation(ENI)and involution-field irradiation(IFI)in elderly patients with esophageal cancer undergoing radical radiotherapy alone.To further explore the feasibility of involving field irradiation in elderly patients.Methods The clinical data of sixty-two elderly patients with esophageal cancer who were admitted to Radiotherapy Center of the Affiliated Hospital of North Sichuan Medical College from January 2018 to January 2020 were retrospectively analyzed.The patients were divided into ENI group(30 cases)and IFI group(32 cases)according to different radiotherapy targets.The progression-free survival rate,overall survival rate,short-term efficacy,radiation pneumonia and radiation esophagitis were compared between the two groups.Results There was no statistical significance in the results of short-term efficacy evaluation between the two groups(P>0.05).There was no statistically significant difference in 1-year and 2-year total survival rate and progression-free survival rate between the two groups(P>0.05).In terms of the incidence of adverse reactions,the incidence of radiation pneumonia(25.00%)and radiation esophagitis(18.75%)in IFI group was significantly lower than that in ENI group,and the difference between the two groups was statistically significant(χ^(2)=4.147,5.522,P<0.05).Conclusion In elderly patients with esophageal cancer receiving radiotherapy alone,IFI and ENI have similar short-term efficacy,progression-free survival and overall survival,but IFI reduces the incidence of radiation pneumonia and radiation esophagitis in elderly patients,making it a more suitable radiotherapy for elderly patients with esophageal cancer.

关 键 词：老年食管癌 累及野照射 淋巴结预防性照射 

分 类 号：R735[医药卫生—肿瘤]