家族性腺瘤性息肉病化学预防药物的研究进展  

Research progress in chemoprevention of familial adenomatous polyposis

作　　者：丁富贵(综述) 禹蓉 董卫国(审校)[1] Ding Fugui;Yu Rong;Dong Weiguo(Department of Gastroenterology,Renmin Hospital of Wuhan University,Hubei Province,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院消化内科,430060

出　　处：《疑难病杂志》2023年第8期885-888,共4页Chinese Journal of Difficult and Complicated Cases

基　　金：湖北省重点研发计划项目(2020BCA066)。

摘　　要：家族性腺瘤性息肉病是一种常染色体显性遗传疾病,其特征是结直肠发生数百个腺瘤性息肉,如果不进行治疗,终生发展为结直肠癌的风险高达100%。目前该病主要的治疗方法是定期内镜下监测并切除较大息肉以及预防性手术切除病变肠段,手术后多发生储袋炎、吻合口狭窄、继发硬纤维瘤等,会严重影响患者的生活质量。化学预防药物或延迟其病情进展可作为一项重要的治疗方法,有研究表明非甾体类抗炎药、二十碳五烯酸、姜黄素、二甲双胍等可能成为有希望的化学预防剂。文章对近年在家族性腺瘤性息肉病化学预防方面取得的研究进展进行综述。Familial adenomatous polyposis is a Autosome dominant genetic disease,which is characterized by hundreds of adenomatous polyps in the colorectal.If not treated,the risk of lifelong development to colorectal cancer is as high as 100%.At present,the main treatment method of the disease is to regularly monitor and remove large polyps under endoscope and perform preventive surgery to remove the diseased intestinal segment.Postoperative pouch inflammation,anastomotic stenosis,secondary rigid Fibroma,etc.,will seriously affect the quality of life of patients.Chemoprevention or delaying the progress of the disease can be used as an important treatment method.Some studies have shown that NSAIDs,eicosapentaenoic acid,Curcumin,Metformin,etc.may become promising chemopreventive agents.This article reviews the research progress in chemoprevention of familial adenomatous polyposis in recent years.

关 键 词：家族性腺瘤性息肉病 化学预防 研究进展 

分 类 号：R735.3[医药卫生—肿瘤]