腹腔热灌注化疗序贯高频热疗治疗恶性腹腔积液的疗效观察  

Observation on the Effect of Malignant Peritoneal Effusion Treated with Hyperthermic Intraperitoneal Chemotherapy Followed by High-Frequency Hyperthermia

作　　者：蒋晓睿 王丽红 赖静 Jiang Xiaorui;Wang Lihong;Lai Jing(Department of Oncology,Chengdu Integrated TCM&Western Medicine Hospital,Chengdu,Sichuan 610000,China)

机构地区：[1]成都市中西医结合医院肿瘤科,四川成都610000

出　　处：《四川医学》2023年第7期689-692,共4页Sichuan Medical Journal

摘　　要：目的 探究恶性腹腔积液患者接受腹腔热灌注化疗序贯高频热疗的疗效。方法 分析我院既往240例恶性腹腔积液患者的资料,根据不同治疗方法分为研究组120例和对照组120例,治疗前均腹腔置管引流腹水,研究组予以腹腔热灌注化疗序贯高频热疗,对照组予以腹腔化疗序贯高频热疗,对比两组患者的近期临床疗效及不良反应,比较两组治疗前后卡氏功能状态(KPS)评分。结果 研究组客观缓解率ORR(83.33%)高于对照组(64.17%),研究组疾病控制率DCR(93.33%)高于对照组(77.50%),差异均有统计学意义(P<0.05)。治疗前两组KPS评分差异无统计学意义(P>0.05);治疗后研究组KPS评分高于对照组,差异有统计学意义(P<0.05),两组患者均存在不良反应,但差异无统计学意义(P>0.05)。结论 腹腔热灌注化疗序贯高频热疗治疗恶性腹腔积液具有较好的效果,不良反应可耐受,疗效显著,患者生存质量有效改善,具有安全、有效与便捷的显著效果。Objective To investigate the effect of Hyperthermic Intraperitoneal Chemotherapy(HIPEC)followed by high-frequency hyperthermia in patients with malignant peritoneal effusion.Methods The medical records of 240 patients with malignant peritoneal effusion were selected.According to the treatment methods,they were divided into two groups:study group and control group,with 120 patients in each group.All patients were given intraperitoneal catheterization to drain ascites before treatment.Patients in the study group were given hyperthermic intraperitoneal chemotherapy followed by high-frequency hyperthermia.Patients in the control group were given intraperitoneal chemotherapy followed by high-frequency hyperthermia.The short-term clinical efficacy and adverse reactions of the two groups were compared,and the KPS scores before and after treatment of the two groups were statistically analyzed.Results The objective remission rate of the study group(83.33%)was higher than that of the control group(64.17%),The disease control rate of the study group(93.33%)was higher than that of the control group(77.50%),with statistically significant difference(P<0.05).There was no significant difference in KPS score between the two groups before treatment(P>0.05).After treatment the KPS score of the study group was higher than that of the control group(P<0.05).Adverse reactions occurred in both groups,but there was no significant difference(P>0.05).Conclusion HIPEC followed by high-frequency hyperthermia had a good effect on the patients with malignant peritoneal effusion,and the adverse reactions were tolerable.Its clinical effect is significant,can effectively improve the quality of life of patients,and the application is safe,effective and convenient.

关 键 词：恶性腹腔积液 腹腔热灌注化疗 高频热疗 腹腔灌注化疗 

分 类 号：R730.5[医药卫生—肿瘤]